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dc.contributor.authorJaved, Asif-
dc.contributor.authorMelé, Marta-
dc.contributor.authorPybus, Marc-
dc.contributor.authorComas, David-
dc.contributor.authorBertranpetit, Jaume-
dc.contributor.authorCalafell, Francesc-
dc.identifier.citationHuman Genetics 131(4): 601-613 (2011)es_ES
dc.description13 páginas.-- Javed, Asif et al.es_ES
dc.description.abstractWe have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,288 individuals (mostly males). We use a novel analysis employing subARG network construction with recombining chromosomal segments. Here, a subARG is constructed independently for each of five gene-free regions across the X chromosome, and the results are aggregated across them. For PCA, MDS and ancestry inference with STRUCTURE, the subARG is processed to obtain feature vectors of samples and pairwise distances between samples. The observed population structure, estimated from the five short X chromosomal segments, supports genome-wide frequency-based analyses: African populations show higher genetic diversity, and the general trend of shared variation is seen across the globe from Africa through Middle East, Europe, Central Asia, Southeast Asia, and East Asia in broad patterns. The recombinational analysis was also compared with established methods based on SNPs and haplotypes. For haplotypes, we also employed a fixed-length approach based on information-content optimization. Our recombinational analysis suggested a southern migration route out of Africa, and it also supports a single, rapid human expansion from Africa to East Asia through South Asia.es_ES
dc.description.sponsorshipThis research is part of the Genographic Project, funded by National Geographic and IBM. Additional funding was provided by the Spanish Ministry of Science and Innovation projects BFU2007-63657, BFU2007-63171, and BFU2010-19443; MM was supported by grant AP2006-03268, Generalitat de Catalunya; OB was supported by Russian Foundation for Basic Research (grants 10-06-00451, 10-04-01603) and by the Presidium RAS Programme “Molecular and Cell Biology”.-
dc.titleRecombination networks as genetic markers in a human variation study of the Old Worldes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderInstituto Nacional de Bioinformática (España)-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderGeneralitat de Catalunya-
dc.contributor.funderRussian Foundation for Basic Research-
dc.contributor.funderNational Geographic Society-
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