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Título

The Advantages and Disadvantages of Sfrp1 and Sfrp2 Expression in Pathological Events

AutorEsteve, Pilar ; Bovolenta, Paola
Palabras claveSecreted frizzled related protein
Wnt signalling
Cancer
Bone repair
Myocardium
Fecha de publicación2010
EditorTohoku University Medical Press
CitaciónTohoku Journal of Experimental Medicine 221(1): 11-17 (2010)
ResumenSecreted Frizzled Related Proteins (Sfrps) are a family of secreted proteins that can bind both to Wnt ligands and Frizzled receptors, thereby modulating the Wnt signalling cascades. Recent studies have shown that Sfrps can also interact with Wnt unrelated molecules such as RANKL, a member of the tumor necrosis factor family, Tolloid metalloproteinases or integrin-fibronectin complexes. Alterations in the levels of Sfrp expression have been recently associated with different pathological conditions, including tumor formation and bone and myocardial disorders. Here, we summarise the evidence that relates Sfrps with these diseases and discuss how the proposed multiple Sfrp interactions with Wnt related and unrelated pathways may explain their implication in such diverse pathologies.
Descripción7 páginas, 1 figura.
Versión del editorhttp://dx.doi.org/10.1620/tjem.221.11
URIhttp://hdl.handle.net/10261/43288
DOI10.1620/tjem.221.11
ISSN0040-8727
E-ISSN1349-3329
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