Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/43234
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Chairi, H. | - |
dc.contributor.author | Fernández-Díez, Cristina | - |
dc.contributor.author | Navas, Jose I. | - |
dc.contributor.author | Manchado, Manuel | - |
dc.contributor.author | Rebordinos, Laureana | - |
dc.contributor.author | Blasco, Julián | - |
dc.date.accessioned | 2011-12-12T13:35:24Z | - |
dc.date.available | 2011-12-12T13:35:24Z | - |
dc.date.issued | 2010-08-03 | - |
dc.identifier.citation | Ecotoxicology and Environmental Safety 73(6): 1279-1285 (2010) | es_ES |
dc.identifier.issn | 0147-6513 | - |
dc.identifier.uri | http://hdl.handle.net/10261/43234 | - |
dc.description | 7 páginas, 4 figuras, 1 tabla. | es_ES |
dc.description.abstract | We have used the comet assay to analyse, after 3 h, 24 h and 6 days, the genotoxic effect in vivo of applying a single intraperitoneal injection of CuSO4, at a concentration of 2 mg/kg, to adult specimens of Solea senegalensis, Dicologlossa cuneata and Scophthalmus rhombus. Metals content (Cu, Zn and Cd) in liver was also measured. The activity of key stress defences was evaluated by analysing antioxidant enzyme activity (catalase (CAT), superoxide dismutase (SOD), total glutathione peroxidase (t-GPX), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH)), metallothionein (MT) and heat shock proteins (HSP70 and HSP60). The results show that CuSO4 intake generates high and cumulative levels of genotoxicity throughout the 6 days in all 3 species. After 6 days, metals content detected in specimens showed significant differences from controls. Inter-species differences were detected in enzyme activity (P<0.05). A clear response to CuSO4 was detected only in S. rhombus, with an increase of MT and a decrease of HSPs. Variations in antioxidant defence levels and their comparative responses to the stress-inducing agent are discussed. | es_ES |
dc.description.sponsorship | This work has been supported financially by the Regional Government (Junta de Andalucia, Spain) in a research project (AGR-516). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Genotoxicity | es_ES |
dc.subject | Flatfish | es_ES |
dc.subject | CuSO4 | es_ES |
dc.subject | Antioxidant enzymes | es_ES |
dc.subject | Stress protein | es_ES |
dc.subject | Comet assay | es_ES |
dc.title | In vivo genotoxicity and stress defences in three flatfish species exposed to CuSO4 | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.ecoenv.2010.07.028 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.ecoenv.2010.07.028 | es_ES |
dc.identifier.e-issn | 1090-2414 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (ICMAN) Artículos |
CORE Recommender
SCOPUSTM
Citations
17
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
15
checked on 22-feb-2024
Page view(s)
347
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.