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Título

A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations

AutorSikora, Martin; Laayouni, Hafid ; Calafell, Francesc ; Comas, David ; Bertranpetit, Jaume
Palabras clavePopulation genetics
Africa
Population history
Fecha de publicación2011
EditorNature Publishing Group
CitaciónEuropean Journal of Human Genetics 19(1): 84-88 (2011)
ResumenStudies of large sets of single nucleotide polymorphism (SNP) data have proven to be a powerful tool in the analysis of the genetic structure of human populations. In this work, we analyze genotyping data for 2841 SNPs in 12 sub-Saharan African populations, including a previously unsampled region of southeastern Africa (Mozambique). We show that robust results in a world-wide perspective can be obtained when analyzing only 1000 SNPs. Our main results both confirm the results of previous studies, and show new and interesting features in sub-Saharan African genetic complexity. There is a strong differentiation of Nilo-Saharans, much beyond what would be expected by geography. Hunter-gatherer populations (Khoisan and Pygmies) show a clear distinctiveness with very intrinsic Pygmy (and not only Khoisan) genetic features. Populations of the West Africa present an unexpected similarity among them, possibly the result of a population expansion. Finally, we find a strong differentiation of the southeastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region.
Versión del editorhttp://dx.doi.org/10.1038/ejhg.2010.141
URIhttp://hdl.handle.net/10261/43220
DOI10.1038/ejhg.2010.141
ISSN1018-4813
E-ISSN1476-5438
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