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http://hdl.handle.net/10261/43061
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Cifuentes, Alejandro | - |
dc.contributor.author | Díez-Masa, José Carlos | - |
dc.contributor.author | Montenegro, Carlos | - |
dc.contributor.author | Rebuelta, Mercedes | - |
dc.contributor.author | Gallardo Ruiz, Alberto | - |
dc.contributor.author | Elvira, Carlos | - |
dc.contributor.author | San Román, Julio | - |
dc.date.accessioned | 2011-12-02T11:39:49Z | - |
dc.date.available | 2011-12-02T11:39:49Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Journal of Biomaterials Science, Polymer Edition 11 (9) : 993-1005 (2000) | es_ES |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | http://hdl.handle.net/10261/43061 | - |
dc.description.abstract | Experimental conditionsfor the fabricationoftwo new polymeric devices (i.e. lms and slabs)useful for the controlled release of recombinant growthhormone(GH) are given. The release rate is controlled by the resorption pro le of the vinylpyrrolidone-hydroxyethyl methacrylate(VP- HEMA) tested systems which is related to the copolymer composition. The suitability of capillary electrophoresis(CE) for followingthe complete preparation of the different VP-HEMA devices is shown. Moreover, CE allows simultaneousmonitoring ofthe controlled release ofGH anddissolved polymer duringin vitroexperiments. From these results, guidelines are given for the fabrication of polymeric devices containing protein as active drugas wellas for the correct selection of conditions during in vitroexperiments | es_ES |
dc.description.sponsorship | Financial support from the Comisión Interministerial de Ciencia y Tecnologia(grant No. MAT96-0981)and Comunidad de Madrid (CAM 08.4/0007) are gratefully acknowledged | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Brill Academic Publishers | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Growthhormone | es_ES |
dc.subject | controlledrelease | es_ES |
dc.subject | vinylpyrrolidone-hydroxyethylmethacrylate | es_ES |
dc.subject | Copolymers | es_ES |
dc.subject | capillary zone electrophoresis | es_ES |
dc.title | Recombinant growth hormone delivery systems based on vinylpyrrolidone-hydroxyethyl methacrylate copolymer matrices : Monitoring optimization by capillary zone electrophoresis | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1163/156856200744156 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1163/156856200744156 | es_ES |
dc.contributor.funder | Comisión Interministerial de Ciencia y Tecnología, CICYT (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007273 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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