English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/4306
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 15 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
Autor : Hortelano, Sonsoles; Zeini, Miriam; Casado, Marta ; Martín-Sanz, Paloma ; Boscá, Lisardo
Palabras clave : Partial Hepatectomy
Nitric Oxide
Prostaglandins
Liver Regeneration
Apoptosis
Animal Models
Review
Fecha de publicación : ene-2007
Editor: Frontiers in Bioscience Publications
Citación : Frontiers in Bioscience 12: 13-21 (2007)
Resumen: The mechanisms that permit adult tissues to regenerate are the object of intense study. Liver regeneration is a research area of considerable interest both from pathological and from physiological perspectives. One of the best models of the regenerative process is the two-thirds partial hepatectomy (PH). After PH, the remnant liver starts a series of timed responses that first favor cell growth and then halts hepatocyte proliferation once liver function is fully restored. The mechanisms regulating this process are complex and involve many cellular events. Initiation of liver regeneration requires the injury-related cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), and involves the activation of cytokine-regulated transcription factors such as NF-kappaB and STAT3. An important event that takes place in the hours immediately after PH is the induction of nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2), and the consequent release of nitric oxide (NO) and prostaglandins (PGs). NO is involved in the vascular readaptation after PH, favoring a general permeability to growth factors throughout the organ. This review examines the mechanisms that regulate NO release during liver regeneration and the animal models used to identify these pathways.
Descripción : This is an, un-copyedited, author manuscript that has been accepted for publication in the Frontiers in Bioscience
URI : http://hdl.handle.net/10261/4306
DOI: 10.2741/2045
Aparece en las colecciones: (IIBM) Artículos
(IBV) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Front Biosci 012-00013.pdf158,22 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.