English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/42915
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

SERS+MEF of the anti-tumoral drug emodin adsorbed on silver nanoparticles

AuthorsSevilla, Paz ; Llanos, Raquel de ; Domingo, Concepción ; Sánchez-Cortés, Santiago ; García-Ramos, José Vicente
KeywordsSilver nanoparticles
MEF
Fluorescence emission
Circular dichroism
Issue Date2010
PublisherThe International Society for Optics and Photonics
CitationProceedings of SPIE 7577: 757714 (2010)
AbstractMetal nanostructures are known to amplify the spontaneous emission of fluorescent molecules by resonant coupling to external electromagnetic fields. We have used spectroscopy to characterize the structural properties of emodin molecules, a natural anthraquinone dye, and bovine serum albumin, the most abundant protein in plasma, in the presence of silver nanoparticles. Aggregation of emodin at pH=10 and pH=6 gives rise to SERS and MEF effects in silver colloid. We have obtained MEF spectra at acidic pH=2.9 using two different silver nanostructures. We have also studied the change in the secondary structure of bovine serum albumin adsorbed on metal nanoparticles surface. Circular dichroism, fluorescence emission and fluorescence lifetime measurements indicate an increase in the alfa-helical content of the protein and a change in the environment of the tryptophan residues that bury in the interior of the biomolecule. This variation on the secondary structure could have further influence in the binding of the drug to form transport and regulatory complexes.
Description5 páginas, 3 figuras, 1 tabla.-- Artículo presentado como póster al SPIE Photonics West 2010, "Plasmonics in Biology and Medicine VII" celebrado en San Francisco (USA) en enero de 2010.
Publisher version (URL)http://dx.doi.org/10.1117/12.839704
URIhttp://hdl.handle.net/10261/42915
DOI10.1117/12.839704
ISSN0277-786X
Appears in Collections:(CFMAC-IEM) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
http___scitation.aip.orgdoi=10.1117_12.pdf769,25 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.