1. DIGITAL.CSIC
  2. Biología y Biomedicina
  3. Instituto de Biología Molecular y Celular de Plantas (IBMCP)
  4. (IBMCP) Artículos
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/42576
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE

Comparte tu historia
de Acceso Abierto
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorGarceau, Valerie-
dc.contributor.authorFares, Mario A.-
dc.contributor.authorHume, David A.-
dc.date.accessioned2011-11-18T11:30:48Z-
dc.date.available2011-11-18T11:30:48Z-
dc.date.issued2010-05-
dc.identifier.citationJournal of Leukocyte Biology 87(5): 753-764 (2010)es_ES
dc.identifier.issn0741-5400-
dc.identifier.urihttp://hdl.handle.net/10261/42576-
dc.description12 páginas, 5 figuras.-- et al.es_ES
dc.description.abstractMacrophages are involved in many aspects of development, host defense, pathology, and homeostasis. Their normal differentiation, proliferation, and survival are controlled by CSF-1 via the activation of the CSF1R. A recently discovered cytokine, IL-34, was shown to bind the same receptor in humans. Chicken is a widely used model organism in developmental biology, but the factors that control avian myelopoiesis have not been identified previously. The CSF-1, IL-34, and CSF1R genes in chicken and zebra finch were identified from respective genomic/cDNA sequence resources. Comparative analysis of the avian CSF1R loci revealed likely orthologs of mammalian macrophage-specific promoters and enhancers, and the CSF1R gene is expressed in the developing chick embryo in a pattern consistent with macrophage-specific expression. Chicken CSF-1 and IL-34 were expressed in HEK293 cells and shown to elicit macrophage growth from chicken BM cells in culture. Comparative sequence and co-evolution analysis across all vertebrates suggests that the two ligands interact with distinct regions of the CSF1R. These studies demonstrate that there are two separate ligands for a functional CSF1R across all vertebrates.es_ES
dc.description.sponsorshipThis work was supported by grant BB/D010705/1 and BBSRC Institute Strategic Program grant to The Roslin Institute.es_ES
dc.language.isoenges_ES
dc.publisherSociety for Leukocyte Biologyes_ES
dc.rightsclosedAccesses_ES
dc.subjectChickenses_ES
dc.subjectZebra finches_ES
dc.subjectMacrophagees_ES
dc.subjectCo-evolutiones_ES
dc.titlePivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene productses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1189/jlb.0909624-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1189/jlb.0909624es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
Aparece en las colecciones: (IBMCP) Artículos
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

142
checked on 10-abr-2024

WEB OF SCIENCETM
Citations

127
checked on 28-feb-2024

Page view(s)

374
checked on 22-abr-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.