English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/42469
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model

AuthorsCalcagnotto, María Elisa ; Zipancic, Ivan; Álvarez-Dolado, Manuel ; Longo, Beatriz M.
KeywordsMaximum electroconvulsive shock
Neural stem cells
GABAergic cells
Tonic seizures
Transplantation
Issue Date1-Jul-2010
PublisherJohn Wiley & Sons
CitationEpilepsia 51(S3): 71-75 (2010)
AbstractMost of the γ-aminobutyric acid (GABA)ergic interneurons in the cerebral cortex originate from restricted regions of the ventral telencephalon known as the caudal and medial ganglionic eminence (MGE) and from the preoptic area. It is well established that dysfunction of GABAergic interneurons can lead to epilepsy. During the last decade new approaches to prevent, reduce, or reverse the epileptic condition have been studied, including cell-based therapy from different sources. Recent studies have shown that transplanted neuronal precursor cells derived from MGE have the ability to migrate, differentiate into inhibitory GABAergic interneurons, and integrate into cortical and hippocampal networks, modifying the inhibitory tone in the host brain. Therefore, transplantation of neuronal precursors derived from MGE into the postnatal central nervous system (CNS) could modify the neuronal circuitry in neurologic diseases in which inhibitory synaptic function is altered, such as in epilepsy. Here, we evaluated the seizure susceptibility of mice transplanted with MGE-derived cells in the maximum electroconvulsive shock (MES) model and we review some data from different studies using GABAergic precursor or GABA-releasing cell grafts in animal models of seizure and epilepsy.
Description5 páginas, 1 figura, 1 tabla.-- Special Issue: 10th Workshop on the Neurobiology of Epilepsy (WONOEP): Novel Therapeutic Approaches to Epileptogenesis.-- et al.
Publisher version (URL)http://dx.doi.org/10.1111/j.1528-1167.2010.02614.x
URIhttp://hdl.handle.net/10261/42469
DOI10.1111/j.1528-1167.2010.02614.x
ISSN0013-9580
E-ISSN1528-1167
Appears in Collections:(CABIMER) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.