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Título : Classical and novel roles of p53 and prospects for anticancer therapy
Autor : Fuster, José J. ; Sanz-González, Silvia M. ; Moll, Ute M.; Andrés, Vicente
Palabras clave : p53
MDM2
Cancer
Aging
Mitochondria
Genetically-engineered mice
Anticancer therapy
Fecha de publicación : may-2007
Editor: Elsevier
Citación : Trends Mol Med 13 (5): 192-199
Resumen: The tumor suppressor p53 is a transcription factor that is frequently inactivated in human tumors. Therefore,restoring its function has been considered an attractive approach to restrain cancer. Typically, p53-dependent growth arrest, senescence and apoptosis of tumor cells have been attributed to transcriptional activity of nuclear p53. Notably, wild-type p53 gain-of-function enhances cancer resistance in the mouse, but it also accelerates aging in some models, possibly due to altered p53 activity. Therefore, the emerging evidence of mitochondrial transcription-independent activities of p53 has raised high expectations. Here, we review new developments in transcription-dependent and transcription-independent p53 functions, recent advances in targeting p53 for cancer treatment and the pitfalls of moving from the laboratory research to the clinical setting.
Descripción : The definitive version is available at http://www.sciencedirect.com/science/journal/14714914
Versión del editor: http://dx.doi.org/10.1016/j.molmed.2007.03.002
URI : http://hdl.handle.net/10261/4227
DOI: 10.1016/j.molmed.2007.03.002
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