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Título: | Classical and novel roles of p53 and prospects for anticancer therapy |
Autor: | Fuster, José J. ![]() ![]() |
Palabras clave: | p53 MDM2 Cancer Aging Mitochondria Genetically-engineered mice Anticancer therapy |
Fecha de publicación: | may-2007 |
Editor: | Elsevier |
Citación: | Trends Mol Med 13 (5): 192-199 |
Resumen: | The tumor suppressor p53 is a transcription factor that is frequently inactivated in human tumors. Therefore,restoring its function has been considered an attractive approach to restrain cancer. Typically, p53-dependent growth arrest, senescence and apoptosis of tumor cells have been attributed to transcriptional activity of nuclear p53. Notably, wild-type p53 gain-of-function enhances cancer resistance in the mouse, but it also accelerates aging in some models, possibly due to altered p53 activity. Therefore, the emerging evidence of mitochondrial transcription-independent activities of p53 has raised high expectations. Here, we review new developments in transcription-dependent and transcription-independent p53 functions, recent advances in targeting p53 for cancer treatment and the pitfalls of moving from the laboratory research to the clinical setting. |
Descripción: | The definitive version is available at http://www.sciencedirect.com/science/journal/14714914 |
Versión del editor: | http://dx.doi.org/10.1016/j.molmed.2007.03.002 |
URI: | http://hdl.handle.net/10261/4227 |
DOI: | 10.1016/j.molmed.2007.03.002 |
Aparece en las colecciones: | (IBV) Artículos |
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Trends Mol Med 013-00192.pdf | 1,64 MB | Adobe PDF | ![]() Visualizar/Abrir |
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