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Title

Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3

AuthorsRuiz-Gómez, Ana ; López-Varea, Ana ; Molnar, Cristina ; Calle-Mustienes, Elisa de la ; Ruiz-Gómez, Mar ; Gómez-Skarmeta, José Luis ; Celis, José F. de
KeywordsCell signaling
MAPK
Vein formation
Negative feedback
Neural development
Drosophila
Xenopus
Issue Date9-Feb-2005
PublisherWiley-Liss
CitationDevelopmental Dynamics 232(3): 695-708 (2005)
AbstractThe extracellular signal-regulated kinase (ERK) is a key transducer of the epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor (FGFR) signaling pathways, and its function is required in multiple processes during animal development. The activity of ERK depends on the phosphorylation state of conserved threonine and tyrosine residues, and this state is regulated by different kinases and phosphatases. A family of phosphatases with specificity toward both threonine and tyrosine residues in ERK (dual-specificity phosphatases) play a conserved role in its dephosphorylation and consequent inactivation. Here, we characterize the function of the dual-specificity phosphatase MKP3 in Drosophila EGFR and Xenopus FGFR signaling. The function of MKP3 is required during Drosophila wing vein formation and Xenopus anteroposterior neural patterning. We find that the expression of the MKP3 gene is localized in places of high EGFR and FGFR signaling. Furthermore, this restricted expression depends on ERK function both in Drosophila and Xenopus, suggesting that MKP3 constitutes a conserved negative feedback loop on the activity of the Ras/ERK signaling pathway.
Description9 páginas, 7 figuras.
Publisher version (URL)http://dx.doi.org/10.1002/dvdy.20227
URIhttp://hdl.handle.net/10261/41859
DOI10.1002/dvdy.20227
ISSN1058-8388
E-ISSN1097-0177
Appears in Collections:(CBM) Artículos
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