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Título: | Emerging therapeutic strategies to enhance HDL function. |
Autor: | Redondo, Santiago CSIC ORCID; Martínez-González, José CSIC ORCID; Urraca, Concha; Tejerina, Teresa | Fecha de publicación: | 10-oct-2011 | Editor: | BioMed Central | Citación: | Lipids in Health and Disease. 10(1):175 (2011) | Resumen: | Abstract Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD). The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT). New insights in HDL biology and RCT have allowed the development of promising agents aimed to increase HDL function and promote atherosclerosis regression. In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD. | URI: | http://hdl.handle.net/10261/41632 | Identificadores: | http://dx.doi.org/10.1186/1476-511X-10-175 |
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1476-511X-10-175.xml | 67,36 kB | XML | Visualizar/Abrir | |
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