Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/41586
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Cloning of mouse ojoplano, a reticular cytoplasmic protein expressed during embryonic development |
Autor: | Mertes, Florián; Martínez-Morales, Juan Ramón CSIC ORCID; Nolden, Tobias; Spörle, Ralf; Wittbrodt, Joachim; Lehrach, Hans; Himmelbauer, Heinz | Palabras clave: | Ojoplano (OPO) Eye anglage Neural retina epithelium Neural crest cells Placodal structures Skeletal expression Mouse embryogenesis OFC1 Orofacial cleft 1 Cleft lip with or without cleft palate In situ hybridization |
Fecha de publicación: | 18-sep-2009 | Editor: | Elsevier | Citación: | Gene Expression Patterns 9(8): 562-567 (2009) | Resumen: | Ojoplano (Opo) is a morphogenetic gene playing an important role during embryogenesis in medaka. This report focuses on the identification and characterization of the mouse Opo gene. We examined Opo expression by whole-mount in situ hybridization and in situ hybridization on sagittal sections during mouse embryogenesis. First expression in whole-mounts was detected at Theiler stages 15–17 (E 9.5–10.5 dpc) as a spotted specific staining in migrating neural crest cells and in placodal structures. A complex expression pattern was observed in Theiler stage 22–23 (E 14.5 dpc) in sagittal sections, including expression in skeletal structures (skull, vertebrae, ribs, bones of the locomotor system), in the nasal region, the heart and the eye. Fusion proteins revealed the localization of OPO within the cytoplasm with a reticular distribution that largely overlapped with the endoplasmic reticulum. Opo shows homology to human transcripts linked to a hereditary craniofacial malformation, orofacial cleft 1 (OFC1). The expression of mouse Opo in neural crest derivatives and skull elements further supports this link. | Descripción: | 6 páginas, 4 figuras, 1 tabla de sequencia de datos (NCBI accession number EU683438). | Versión del editor: | http://dx.doi.org/10.1016/j.gep.2009.09.003 | URI: | http://hdl.handle.net/10261/41586 | DOI: | 10.1016/j.gep.2009.09.003 | ISSN: | 1567-133X |
Aparece en las colecciones: | (CABD) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
6
checked on 09-mar-2024
WEB OF SCIENCETM
Citations
6
checked on 22-feb-2024
Page view(s)
296
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.