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Título

Cloning of mouse ojoplano, a reticular cytoplasmic protein expressed during embryonic development

AutorMertes, Florián; Martínez-Morales, Juan Ramón CSIC ORCID; Nolden, Tobias; Spörle, Ralf; Wittbrodt, Joachim; Lehrach, Hans; Himmelbauer, Heinz
Palabras claveOjoplano (OPO)
Eye anglage
Neural retina epithelium
Neural crest cells
Placodal structures
Skeletal expression
Mouse embryogenesis
OFC1
Orofacial cleft 1
Cleft lip with or without cleft palate
In situ hybridization
Fecha de publicación18-sep-2009
EditorElsevier
CitaciónGene Expression Patterns 9(8): 562-567 (2009)
ResumenOjoplano (Opo) is a morphogenetic gene playing an important role during embryogenesis in medaka. This report focuses on the identification and characterization of the mouse Opo gene. We examined Opo expression by whole-mount in situ hybridization and in situ hybridization on sagittal sections during mouse embryogenesis. First expression in whole-mounts was detected at Theiler stages 15–17 (E 9.5–10.5 dpc) as a spotted specific staining in migrating neural crest cells and in placodal structures. A complex expression pattern was observed in Theiler stage 22–23 (E 14.5 dpc) in sagittal sections, including expression in skeletal structures (skull, vertebrae, ribs, bones of the locomotor system), in the nasal region, the heart and the eye. Fusion proteins revealed the localization of OPO within the cytoplasm with a reticular distribution that largely overlapped with the endoplasmic reticulum. Opo shows homology to human transcripts linked to a hereditary craniofacial malformation, orofacial cleft 1 (OFC1). The expression of mouse Opo in neural crest derivatives and skull elements further supports this link.
Descripción6 páginas, 4 figuras, 1 tabla de sequencia de datos (NCBI accession number EU683438).
Versión del editorhttp://dx.doi.org/10.1016/j.gep.2009.09.003
URIhttp://hdl.handle.net/10261/41586
DOI10.1016/j.gep.2009.09.003
ISSN1567-133X
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