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http://hdl.handle.net/10261/41433
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Sierra-Filardi, Elena | - |
dc.contributor.author | Vega Palacios, Miguel A. | - |
dc.contributor.author | Sánchez-Mateos, Paloma | - |
dc.contributor.author | Corbí, Angel L. | - |
dc.contributor.author | Puig-Kröger, Amaya | - |
dc.date.accessioned | 2011-10-19T17:27:41Z | - |
dc.date.available | 2011-10-19T17:27:41Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | Immunobiology, 215(9-10):788-795 (2010) | es_ES |
dc.identifier.issn | 1878-3279 | - |
dc.identifier.uri | http://hdl.handle.net/10261/41433 | - |
dc.description.abstract | The shift between pro-inflammatory (M1) and anti-inflammatory (M2) states of macrophage polarization allows the resolution of inflammatory processes as well as the maintenance of a basal anti-inflammatory environment in tissues continuously exposed to harmless antigens (e.g., lung and gut). To identify markers for the anti-inflammatory state of macrophages, expression profiling was performed on human macrophages polarized by either GM-CSF or M-CSF, which lead to the generation of TNF-α and IL-12p40-producing pro-inflammatory macrophages [M1 (GM-CSF)] or IL-10-producing anti-inflammatory macrophages [M2 (M-CSF)] upon exposure to LPS, respectively. A different iron metabolism gene signature was detected in both macrophage types, with the heme regulatory molecules CD163 and Heme Oxygenase-1 (HO-1) being preferentially expressed by M2 (M-CSF) macrophages. M1-polarizing cytokines (GM-CSF, IFNγ) inhibited, while IL-4 enhanced, the M-CSF-driven HO-1 expression. In agreement with this in vitro data, HO-1 expression in metastatic melanoma was primarily detected in CD163+ tumor-associated macrophages, which are known to exhibit an M2-skewed polarization phenotype. In contrast to the HO-1 inhibitor tin protoporphyrin (SnPP), the administration of cobalt protoporphyrin (CoPP), a potent inducer of HO-1 resulted in increased LPS-triggered IL-10 release from M2 (M-CSF) macrophages. The data suggests that HO-1 is important for the anti-inflammatory activities of M-CSF-polarized M2 macrophages. Moreover, since M2 (M-CSF) macrophages also express higher levels of the CD163 scavenger receptor, the CD163/HO-1/IL-10 axis appears to contribute to the generation of an immunosuppressive environment within the tumor stroma. | es_ES |
dc.description.sponsorship | This work was supported by the Ministerio de Educación y Ciencia (Grant BFU2008-01493-BMC), Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (Spanish Network for the Research in Infectious Diseases, REIPI RD06/0008, and AIDS Research Network, RIS RD06/0006), and Fundación para la Investigación y Prevención del SIDA en España (FIPSE 36663/07) to ALC, and grant PI08/1208 from Instituto de Salud Carlos III to APK. APK is supported by Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (CP06/00199). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Heme Oxygenase-1 | es_ES |
dc.subject | Tumor-associated macrophages | es_ES |
dc.subject | CD163 | es_ES |
dc.subject | Interleukin-10 | es_ES |
dc.subject | Metalloporphyrins | es_ES |
dc.subject | Tumor Necrosis Factor-alpha (TNF-α) | es_ES |
dc.subject | Melanoma | es_ES |
dc.subject | Cell differentiation | es_ES |
dc.subject | Interleukin-12 subunit p40 | es_ES |
dc.subject | Gene expression profiling | es_ES |
dc.title | Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release. | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.imbio.2010.05.020 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0171298510000860 | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.imbio.2010.05.020 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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