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dc.contributor.authorKrupinski, Jerzy-
dc.contributor.authorMiguel Turu, Marta-
dc.contributor.authorFont, M.ª Angels-
dc.contributor.authorCatena, Esther-
dc.contributor.authorSlevin, Mark-
dc.contributor.authorMorchón, Sergio-
dc.contributor.authorRubio, Francisco-
dc.contributor.authorBadimón, Lina-
dc.contributor.authorMartínez-González, José-
dc.date.accessioned2008-05-09T14:48:01Z-
dc.date.available2008-05-09T14:48:01Z-
dc.date.issued2007-11-22-
dc.identifier.citationCerebrovascular Diseases 25(1-2): 32-39 (2008).en_US
dc.identifier.issn1015-9770-
dc.identifier.urihttp://hdl.handle.net/10261/4131-
dc.description.abstract[Background] Tissue factor (TF) expression is increased in inflammatory atherosclerotic plaques and has been related to plaque thrombogenicity. Blood-borne TF activity seems to contribute to a procoagulant state in patients with vascular risk factors. The aim of this study was to assess whether the expression of TF in carotid plaques from patients undergoing carotid endarterectomy (CEA) or/and blood-borne ('circulating') TF activity could predict future vascular complications.en_US
dc.description.abstract[Methods] A total of 105 consecutive patients (85 male and 20 female aged 61-77years)undergoing CEA for high-grade internal carotid artery were included in the study. Carotid artery specimens were classified into active (n = 52; rich in inflammatory cells) and nonactive plaques (n = 53; poor in inflammatory cells or fibrous). TF mRNA levels in carotid plaques were assessed by real-time PCR (TaqMan Low-Density Arrays) and TF protein levels by Western blot. Blood-borne TF activity and other biochemical parameters, including low-density lipoprotein cholesterol (LDLc) levels and high-sensitivity C-reactive protein, were measured prior to surgery. Patients were followed up for 1 year and vascular and nonvascular complications were scored.en_US
dc.description.abstract[Results] TF expression was higher in active CEA plaques. Patients with active CEA plaques exhibited higher plasma LDLc levels (3.6 ± 0.7 vs. 2.1 ± 1 mM, p < 0.05) that positively correlated with plaque TF mRNA levels (p = 0.0125; r = 0.9). Blood-borne TF activity did not correlate with plasma LDLc levels and was unrelated to the anatomo-pathological characteristic of the CEA plaques (thrombosis, rupture, inflammation, lipid core, necrosis or calcification). Circulating TF activity predicted vascular complications at 1 year, including fatal (OR, 1.18; 95% CI, 0.6-2.2, p < 0.01) and nonfatal ischemic stroke (OR, 1.22; 95% CI, 0.5-2.0, p < 0.05) and symptomatic peripheral vascular disease (OR, 1.48; 95% CI, 0.4-2.6, p < 0.005).en_US
dc.description.abstract[Conclusions] Blood-borne TF activity prior to CEA but not local TF expression or plasma LDLc levels predict cerebrovascular and peripheral vascular disease events at 1 year in elderly patients subjected to CEA for high-grade carotid stenosis.en_US
dc.format.extent22195 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherS. Karger AGen_US
dc.rightsclosedAccessen_US
dc.subjectTissue factoren_US
dc.subjectCarotid endarterectomyen_US
dc.subjectCarotid plaquesen_US
dc.titleBlood-borne tissue factor activity predicts major cerebrovascular events in patients undergoing carotid endarterectomy: results from a 1-year follow-up studyen_US
dc.typeArtículoen_US
dc.identifier.doi10.1159/000111497-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1159/000111497-
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