English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/4123
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit

AuthorsBadimón, Juan José; Badimón Maestro, Lina; Fuster, Valentín
KeywordsAtherosclerosis
Cholesterol-fed rabbit
HDL-VHDL
Regression
Lipoprotein
Issue DateApr-1990
PublisherAmerican Society for Clinical Investigation
CitationJ Clin Invest. 85(4): 1234–1241 (1990).
AbstractThe effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich diet for 60 d (group 1). Another group of animals were maintained on the same diet for 90 d (group 2). A third group was also fed the same diet for 90 d but received 50 mg HDL-VHDL protein per wk (isolated from normolipemic rabbit plasma) during the last 30 d (group 3). Aortic atherosclerotic involvement at the completion of the study was 34 ± 4% in group 1, 38.8 ± 5% in group 2, and 17.8 ± 4% in group 3 (P < 0.005). Aortic lipid deposition was also significantly reduced in group 3 compared with group 1 (studied at only 60 d) and group 2. This is the first in vivo, prospective evidence of the antiatherogenic effect of HDLVHDL against preexisting atherosclerosis. Our results showed that HDL plasma fractions were able to induce regression of established aortic fatty streaks and lipid deposits. Our results suggest that it may be possible not only to inhibit progression but even to reduce established atherosclerotic lesions by HDL administration.
DescriptionPMCID: PMC296557
URIhttp://hdl.handle.net/10261/4123
DOI10.1172/JCI114558
ISSN0021-9738
Appears in Collections:(CIC) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.