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dc.contributor.authorParrado-Fernández, Cristina-
dc.contributor.authorLópez-Lluch, Guillermo-
dc.contributor.authorRodríguez-Bies, Elisabet-
dc.contributor.authorSanta-Cruz Calvo, Sara-
dc.contributor.authorNavas, Plácido-
dc.contributor.authorRamsey, Jon J.-
dc.contributor.authorVillalba, José M.-
dc.date.accessioned2011-10-17T10:06:55Z-
dc.date.available2011-10-17T10:06:55Z-
dc.date.issued2011-03-27-
dc.identifier.citationFree Radical Biology and Medicine 50(12): 1728-1736 (2011)es_ES
dc.identifier.issn0891-5849-
dc.identifier.otherPMID: 21447381-
dc.identifier.urihttp://hdl.handle.net/10261/41204-
dc.description9 páginas, 5 figuras, 1 tabla.es_ES
dc.description.abstractWe studied ubiquinone (Q), Q homologue ratio, and steady-state levels of mCOQ transcripts in tissues from mice fed ad libitum or under calorie restriction. Maximum ubiquinone levels on a protein basis were found in kidney and heart, followed by liver, brain, and skeletal muscle. Liver and skeletal muscle showed the highest Q9/Q10 ratios with significant interindividual variability. Heart, kidney, and particularly brain exhibited lower Q9/Q10 ratios and interindividual variability. In skeletal muscle and heart, the most abundant mCOQ transcript was mCOQ7, followed by mCOQ8, mCOQ2, mPDSS2, mPDSS1, and mCOQ3. In nonmuscular tissues (liver, kidney, and brain) the most abundant mCOQ transcript was mCOQ2, followed by mCOQ7, mCOQ8, mPDSS1, mPDSS2, and mCOQ3. Calorie restriction increased both ubiquinone homologues and mPDSS2 mRNA in skeletal muscle, but mCOQ7 was decreased. In contrast, Q9 and most mCOQ transcripts were decreased in heart. Calorie restriction also modified the Q9/Q10 ratio, which was increased in kidney and decreased in heart without alterations in mPDSS1 or mPDSS2 transcripts. We demonstrate for the first time that unique patterns of mCOQ transcripts exist in muscular and nonmuscular tissues and that Q and COQ genes are targets of calorie restriction in a tissue-specific way.es_ES
dc.description.sponsorshipThis work was supported by NIH Grant 1R01AG028125-01A1 (to J.J.R., P.N., and J.M.V.), Junta de Andalucía Proyectos de Excelencia Grant CVI-00648 (to P.N.), Junta de Andalucía Proyectos de Excelencia Grant P09-CVI-4887 (to J.M.V.), a Junta de Andalucía Proyectos Internacionales grant (to J.M.V.), and BIO-276 (Junta de Andalucía and the University of Córdoba, to J.M.V.). C.P. was funded by Grant CVI-00648.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprint-
dc.rightsopenAccesses_ES
dc.subjectCalorie restrictiones_ES
dc.subjectCOQ transcriptses_ES
dc.subjectUbiquinonees_ES
dc.subjectUbiquinone biosynthesises_ES
dc.subjectFree radicalses_ES
dc.subjectBraines_ES
dc.subjectMyocardiumes_ES
dc.subjectCoenzyme Q10es_ES
dc.titleCalorie restriction modifies ubiquinone and COQ transcript levels in mouse tissueses_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1016/j.freeradbiomed.2011.03.024-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.03.024es_ES
dc.contributor.funderJunta de Andalucía-
dc.contributor.funderUniversidad de Córdoba (España)-
dc.contributor.funderNational Institutes of Health (US)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.pmid21447381-
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