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dc.contributor.authorBautista-Ferrufino, María Rosa-
dc.contributor.authorCordero, Mario D.-
dc.contributor.authorSánchez-Alcázar, José Antonio-
dc.contributor.authorIllanes, Matilde-
dc.contributor.authorFernández-Rodríguez, Ana-
dc.contributor.authorNavas, Plácido-
dc.contributor.authorMiguel, Manuel de-
dc.date.accessioned2011-10-14T09:39:06Z-
dc.date.available2011-10-14T09:39:06Z-
dc.date.issued2011-04-09-
dc.identifier.citationToxicology Letters 204(1): 32-37 (2011)es_ES
dc.identifier.issn0378-4274-
dc.identifier.otherPMID: 21501668-
dc.identifier.urihttp://hdl.handle.net/10261/41117-
dc.description6 páginas, 4 figuras.es_ES
dc.description.abstractAmitriptyline is a tricyclic antidepressant commonly prescribed for the treatment of several neuropathic and inflammatory illnesses. We have already reported that amitriptyline has cytotoxic effect in human cell cultures, increasing oxidative stress, and decreasing growth rate and mitochondrial activity. Coenzyme Q (CoQ), a component of the respiratory chain and a potent antioxidant, has been proposed as a mitochondrial dysfunction marker. In the present work we evaluated lipid peroxidation, a consequence of oxidative stress, and CoQ level in liver, lung, kidney, brain, heart, skeletal muscle, and serum of mice treated with amitriptyline for two weeks. Lipid peroxidation was increased in a dose-dependent manner in all tissues analyzed. CoQ levels were increased in brain, heart, skeletal muscle, and serum, and strongly decreased in liver and lung. The relation between amitriptyline, CoQ, and oxidative stress is discussed.es_ES
dc.description.sponsorshipThis work has been partially supported by IV Plan Propio de Investigación (University of Seville, ref. 2010/00000453).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectAmitriptylinees_ES
dc.subjectCoenzyme Qes_ES
dc.subjectLipid peroxidationes_ES
dc.subjectOxidative stresses_ES
dc.subjectAntidepressive agentses_ES
dc.subjectUbiquinonees_ES
dc.titleAmitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liveres_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1016/j.toxlet.2011.03.033-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.toxlet.2011.03.033es_ES
dc.contributor.funderUniversidad de Sevilla-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/100009042es_ES
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