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Título

Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver

AutorBautista-Ferrufino, María Rosa; Cordero, Mario D. ; Sánchez-Alcázar, José Antonio ; Illanes, Matilde; Fernández-Rodríguez, Ana; Navas, Plácido ; Miguel, Manuel de
Palabras claveAmitriptyline
Coenzyme Q
Lipid peroxidation
Oxidative stress
Antidepressive agents
Ubiquinone
Fecha de publicación9-abr-2011
EditorElsevier
CitaciónToxicology Letters 204(1): 32-37 (2011)
ResumenAmitriptyline is a tricyclic antidepressant commonly prescribed for the treatment of several neuropathic and inflammatory illnesses. We have already reported that amitriptyline has cytotoxic effect in human cell cultures, increasing oxidative stress, and decreasing growth rate and mitochondrial activity. Coenzyme Q (CoQ), a component of the respiratory chain and a potent antioxidant, has been proposed as a mitochondrial dysfunction marker. In the present work we evaluated lipid peroxidation, a consequence of oxidative stress, and CoQ level in liver, lung, kidney, brain, heart, skeletal muscle, and serum of mice treated with amitriptyline for two weeks. Lipid peroxidation was increased in a dose-dependent manner in all tissues analyzed. CoQ levels were increased in brain, heart, skeletal muscle, and serum, and strongly decreased in liver and lung. The relation between amitriptyline, CoQ, and oxidative stress is discussed.
Descripción6 páginas, 4 figuras.
Versión del editorhttp://dx.doi.org/10.1016/j.toxlet.2011.03.033
URIhttp://hdl.handle.net/10261/41117
DOI10.1016/j.toxlet.2011.03.033
ISSN0378-4274
ReferenciasPMID: 21501668
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