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Título: | Sex steroids modulate luteinizing hormone-releasing hormone secretion in a cholinergic cell line from the basal forebrain |
Autor: | Martínez-Morales, Juan Ramón CSIC ORCID; López-Coviella, I.; Hernández-Jiménez, J. G.; Reyes, R.; Bello, A. R.; Hernández, G.; Blusztajn, J. K.; Alonso, Rafael | Palabras clave: | SN56 cells Acetylcholine Choline acetyltransferase Sex steroids Estrogen receptor Progesterone receptor Septum |
Fecha de publicación: | 5-abr-2001 | Editor: | Elsevier | Citación: | Neuroscience 103(4): 1025-1031 (2001) | Resumen: | The function of a particular neuronal population is in part determined by its neurotransmitter phenotype. We have found that a neuronal-derived septal cell line (SN56), known for its cholinergic properties, also synthesizes and releases luteinizing hormone-releasing hormone. In addition, these cells express the messenger RNAs encoding estrogen and progesterone receptors. The activation of these receptors by their respective ligands cooperatively modulates the depolarization-induced release of luteinizing hormone-releasing hormone in these cells. We have also found that a number of septal neurons in postnatal (1-week-old) mice are immunoreactive to both choline acetyltransferase and luteinizing hormone-releasing hormone. These results indicate that both neurotransmitters, acetylcholine and luteinizing hormone-releasing hormone, may co-exist in septal neurons of the CNS and that they could be modulated by gonadal hormones, and suggest that luteinizing hormone-releasing hormone could be involved in some of the actions of sex steroids on cholinergic neurotransmission. | Descripción: | 7 páginas, 3 figuras, 1 tabla. | Versión del editor: | http://dx.doi.org/10.1016/S0306-4522(01)00023-9 | URI: | http://hdl.handle.net/10261/41088 | DOI: | 10.1016/S0306-4522(01)00023-9 | ISSN: | 0306-4522 | E-ISSN: | 1873-7544 |
Aparece en las colecciones: | (CABD) Artículos |
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