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Title

Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α-synuclein complex by Hip

AuthorsRoodveldt, Cintia ; Fernández Montesinos, Rafael ; Pozo, David ; Dobson, Christopher M.
KeywordsAmyloid
Hip
Hsp70
Parkinson's disease
α-synuclein
Issue Date2009
PublisherNature Publishing Group
European Molecular Biology Organization
CitationEMBO Journal 28(23): 3758-3770 (2009)
AbstractThe ATP-dependent protein chaperone heat-shock protein 70 (Hsp70) displays broad anti-aggregation functions and has a critical function in preventing protein misfolding pathologies. According to in vitro and in vivo models of Parkinson's disease (PD), loss of Hsp70 activity is associated with neurodegeneration and the formation of amyloid deposits of α-synuclein (αSyn), which constitute the intraneuronal inclusions in PD patients known as Lewy bodies. Here, we show that Hsp70 depletion can be a direct result of the presence of aggregation-prone polypeptides. We show a nucleotide-dependent interaction between Hsp70 and αSyn, which leads to the aggregation of Hsp70, in the presence of ADP along with αSyn. Such a co-aggregation phenomenon can be prevented in vitro by the co-chaperone Hip (ST13), and the hypothesis that it might do so also in vivo is supported by studies of a Caenorhabditis elegans model of αSyn aggregation. Our findings indicate that a decreased expression of Hip could facilitate depletion of Hsp70 by amyloidogenic polypeptides, impairing chaperone proteostasis and stimulating neurodegeneration.
Description13 páginas, 6 figuras.-- et al.
Publisher version (URL)http://dx.doi.org/10.1038/emboj.2009.298
URIhttp://hdl.handle.net/10261/40966
DOI10.1038/emboj.2009.298
ISSN0261-4189
E-ISSN1460-2075
Appears in Collections:(CABIMER) Artículos
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