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Título : Genome instability: a mechanistic view of its causes and consequences
Autor : Aguilera, Andrés ; Gómez-González, Belén
Palabras clave : Genomic instability
Mutations
Mechanics
Fecha de publicación : mar-2008
Editor: Nature Publishing Group
Citación : Nature Reviews Genetics 9: 204-217 (2008)
Resumen: Genomic instability in the form of mutations and chromosome rearrangements is usually associated with pathological disorders, and yet it is also crucial for evolution. Two types of elements have a key role in instability leading to rearrangements: those that act in trans to prevent instability -among them are replication, repair and S-phase checkpoint factors- and those that act in cis -chromosomal hotspots of instability such as fragile sites and highly transcribed DNA sequences. Taking these elements as a guide, we review the causes and consequences of instability with the aim of providing a mechanistic perspective on the origin of genomic instability.
Descripción : 14 páginas, 6 figuras, 1 tabla. PMID: 18227811.-- Final full-text version of the paper available at: http://dx.doi.org/10.1038/nrg2268.-- Supplementary material available at: http://www.nature.com/nrg/journal/v9/n3/extref/nrg2268-s1.pdf
Versión del editor: http://dx.doi.org/10.1038/nrg2268
URI : http://hdl.handle.net/10261/4094
DOI: 10.1038/nrg2268
ISSN: 1471-0056
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