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dc.contributor.authorLuna, Rosa-
dc.contributor.authorGaillard, Hélène-
dc.contributor.authorGonzález-Aguilera, Cristina-
dc.contributor.authorAguilera, Andrés-
dc.date.accessioned2008-05-08T14:59:53Z-
dc.date.available2008-05-08T14:59:53Z-
dc.date.issued2008-04-22-
dc.identifier.citationChromosoma. 2008 Apr 22 [Epub ahead of print]en_US
dc.identifier.issn0009-5915-
dc.identifier.urihttp://hdl.handle.net/10261/4093-
dc.descriptionPMID: 18427828.-- Final full-text version of the paper available at: http://dx.doi.org/10.1007/s00412-008-0158-4 (www.springerlink.com)en_US
dc.description.abstractTranscription is a central function occurring in the nucleus of eukaryotic cells in coordination with other nuclear processes. During transcription, the nascent pre-mRNA associates with mRNA-binding proteins and undergoes a series of processing steps, resulting in export-competent mRNA ribonucleoprotein complexes (mRNPs) that are transported into the cytoplasm. Experimental evidence increasingly indicates that the different processing steps (5′-end capping, splicing, 3′-end cleavage) and mRNP export are connected to each other as well as to transcription, both functionally and physically. Here, we review the overall process of mRNP biogenesis with particular emphasis on the functional coupling of transcription with mRNP biogenesis and export and its relationship to nuclear organization.en_US
dc.description.sponsorshipResearch in A.A.’s lab is funded by grants from the Spanish Ministry of Science and Education (BFU2006-05260 and Consolider Ingenio 2010 CDS2007-0015) and from the Junta de Andalucía (CVI102 and CVI624).en_US
dc.format.extent22195 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsclosedAccessen_US
dc.subjectTranscriptionen_US
dc.subjectmRNAen_US
dc.subjectmRNA ribonucleoprotein complexes (mRNPs)en_US
dc.subjectmRNP biogenesisen_US
dc.titleBiogenesis of mRNPs: integrating different processes in the eukaryotic nucleusen_US
dc.typeArtículoen_US
dc.identifier.doi10.1007/s00412-008-0158-4-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1007/s00412-008-0158-4-
dc.identifier.e-issn1432-0886-
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