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Título

Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus

AutorLuna, Rosa ; Gaillard, Hélène ; González-Aguilera, Cristina ; Aguilera, Andrés
Palabras claveTranscription
mRNA
mRNA ribonucleoprotein complexes (mRNPs)
mRNP biogenesis
Fecha de publicación22-abr-2008
EditorSpringer
CitaciónChromosoma. 2008 Apr 22 [Epub ahead of print]
ResumenTranscription is a central function occurring in the nucleus of eukaryotic cells in coordination with other nuclear processes. During transcription, the nascent pre-mRNA associates with mRNA-binding proteins and undergoes a series of processing steps, resulting in export-competent mRNA ribonucleoprotein complexes (mRNPs) that are transported into the cytoplasm. Experimental evidence increasingly indicates that the different processing steps (5′-end capping, splicing, 3′-end cleavage) and mRNP export are connected to each other as well as to transcription, both functionally and physically. Here, we review the overall process of mRNP biogenesis with particular emphasis on the functional coupling of transcription with mRNP biogenesis and export and its relationship to nuclear organization.
DescripciónPMID: 18427828.-- Final full-text version of the paper available at: http://dx.doi.org/10.1007/s00412-008-0158-4 (www.springerlink.com)
Versión del editorhttp://dx.doi.org/10.1007/s00412-008-0158-4
URIhttp://hdl.handle.net/10261/4093
DOI10.1007/s00412-008-0158-4
ISSN0009-5915 (Print)
1432-0886 (Online)
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