Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/40883
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Fernández-Miñán, Ana | - |
dc.contributor.author | Cobreros, Laura | - |
dc.contributor.author | González-Reyes, Acaimo | - |
dc.contributor.author | Martín-Bermudo, María D. | - |
dc.date.accessioned | 2011-10-10T11:22:20Z | - |
dc.date.available | 2011-10-10T11:22:20Z | - |
dc.date.issued | 2008-08-08 | - |
dc.identifier.citation | International Journal of Development Biology 52(7): 925-932 (2008) | es_ES |
dc.identifier.issn | 0214-6282 | - |
dc.identifier.other | PMID: 18956322 | - |
dc.identifier.uri | http://hdl.handle.net/10261/40883 | - |
dc.description | 8 páginas, 5 figuras. | es_ES |
dc.description.abstract | The generation of epithelial cell polarity is a key process during development. Although the induction and orientation of cell polarity by cell-cell and cell-extracellular matrix (ECM) interactions is well established, the molecular mechanisms by which signals from the ECM control cell polarity in developing epithelial tissues remain poorly understood. Here, we have used the follicular epithelium of the Drosophila ovary to investigate the role that integrins, the main cell-ECM receptors, play in the establishment of apicobasal polarity. Mature follicle cells have an apical side facing the germ line and a basal side in contact with a basement membrane. Our results show that integrins - presumably via interactions with the basement membrane - play a reinforcing role in follicle cell polarization, as they are required to establish and/or maintain follicle cell membrane asymmetry only when contact with the germ line is prevented. We suggest that the primary cue for polarization of the follicular epithelium is contact with the germline cells. In addition, while interfering with apical and lateral polarization cues leads to apoptosis, we show here that inhibition of contact with the basement membrane mediated by integrins does not affect cell survival. Finally, we provide evidence to suggest that integrins are required to orientate epithelial polarity in vivo. | es_ES |
dc.description.sponsorship | We thank the Bloomington Stock Centre for fly stocks. Research in our laboratories is funded by the Spanish Ministerio de Ciencia y Tecnología(MCYT) (BFU2006-10934 to A.G-R; BFU2004-02840/BMC to M.D.M-B),by the EMBO Young Investigator Programme and by the Junta deAndalucía (CVI-280 and PO6-CVI-01592). L. C-R was supported by afellowship funded by the EMBO Young Investigator Programme and A. F-M was supported by a FPI studentship from the MCYT and by an I3P-CSIC contract. The institutional support from the Junta de Andalucía tothe CABD is acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | University of British Columbia Press | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Integrin | es_ES |
dc.subject | Apicobasal polarity | es_ES |
dc.subject | Basement membrane | es_ES |
dc.subject | Epithelial polarity | es_ES |
dc.subject | Drosophila | es_ES |
dc.subject | Ovarian lollicle | es_ES |
dc.title | Integrins contribute to the establishment and maintenance of cell polarity in the follicular epithelium of the Drosophila ovary | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1387/ijdb.072418af | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http:/dx.doi.org/10.1387/ijdb.072418af | es_ES |
dc.identifier.e-issn | 1696-3547 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (CABD) Artículos |
CORE Recommender
SCOPUSTM
Citations
18
checked on 20-mar-2024
WEB OF SCIENCETM
Citations
18
checked on 23-feb-2024
Page view(s)
289
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.