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Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton

AutorBolívar, Jorge; Huynh, Jean-René; López-Schier, Hernán; González, Cayetano; St Johnston, Daniel; González-Reyes, Acaimo
Palabras claveDrosophila oogenesis
Oocyte determination
Fecha de publicación19-abr-2001
EditorCompany of Biologists
CitaciónDevelopment 128, 1889-1909 (2001).
ResumenDuring early Drosophila oogenesis, one cell from a cyst of 16 germ cells is selected to become the oocyte, and accumulates oocyte-specific proteins and the centrosomes from the other 15 cells. Here we show that the microtubule cytoskeleton and the centrosomes follow the same stepwise restriction to one cell as other oocyte markers. Surprisingly, the centrosomes still localise to one cell after colcemid treatment, and in BicD and egl mutants, which abolish the localisation of all other oocyte markers and the polarisation of the microtubule cytoskeleton. In contrast, the centrosomes fail to migrate in cysts mutant for Dynein heavy chain 64C, which disrupts the fusome. Thus, centrosome migration is independent of the organisation of the microtubule cytoskeleton, and seems to depend instead on the polarity of the fusome.
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