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A novel mutant phenotype implicates dicephalic in cyst formation in the Drosophila ovary

AutorMcCaffrey, Ruth; St Johnston, Daniel; González-Reyes, Acaimo
Palabras claveDrosophila oogenesis
Oocyte positioning
Pattern formation
Fecha de publicaciónabr-2006
EditorJohn Wiley & Sons
CitaciónDevelopmental Dynamics 235(4): 908-917 (2006)
ResumenThe establishment of polarity in Drosophila requires the correct specification of the oocyte in early stages of oogenesis, its positioning at the posterior of the egg chamber, and signalling events between the oocyte and the adjacent posterior follicle cells. As a consequence, the anterior-posterior and the dorsal-ventral axes are fixed. The posterior localisation of the oocyte depends on cadherin-mediated adhesion between the oocyte and the follicle cells. Here we show that dicephalic mutants affect the posterior positioning of the oocyte without interfering with oocyte specification in the germarium. Unlike other mutants that also affect the posterior placement of the oocyte, dicephalic mutants affect neither gurken expression nor karyosome formation during meiosis. By analysing in detail the mutant phenotypes of dicephalic, we find that cyst formation in mutant germaria is defective and that it shares some similarities with cysts that lack DE-cadherin in the germline cells. We propose a model in which dicephalic is involved in the proper adhesion between the oocyte and the somatic follicle cells.
DescripciónFinal full-text version available at: http://dx.doi.org/10.1002/dvdy.20620.-- Published online 28 October 2005 in Wiley InterScience (www.interscience.wiley.com).
Versión del editorhttp://dx.doi.org/10.1002/dvdy.20620
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