English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/40692
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Integrated Response to Inducers by Communication between a Catabolic Pathway and Its Regulatory System

AuthorsMartínez-Pérez, Olga; López-Sánchez, Aroa ; Reyes-Ramírez, Francisca ; Floriano Pardal, Belén ; Santero, Eduardo
Energy metabolism
Escherichia coli
Lac operon
Issue DateMay-2007
PublisherAmerican Society for Microbiology
CitationJournal of Bacteriology 189(10): 3768-3775 (2007)
AbstractEfficient gene regulation of metabolic pathways implies that the profile of molecules inducing the pathway matches that of the molecules that are metabolized. Gratuitous induction, a well-known phenomenon in catabolic pathways, is the consequence of differences in the substrate and inducer profiles. This phenomenon is particularly evident in pathways for biodegradation of organic contaminants that can be induced by a variety of molecules similar to the real substrates. Analysis of the regulation of tetralin biodegradation genes in mutant strains with mutations that affect each component of the initial dioxygenase enzymatic complex indicated that the response of the regulatory system to potential inducers is altered differently depending on the mutated component. Based on the expression phenotypes of a number of single or double mutants, we propose a model that represents an unprecedented way of communication between a catabolic pathway and its regulatory system to prevent efficient induction by a molecule that is not a real substrate. This communication allows a better fit of the substrate and inducer profiles, thus minimizing gratuitous induction, without a requirement for optimal coevolution to match the specificity of catabolic enzymes and their regulatory systems. Modulation of the regulatory system in this way not only provides a more appropriate response to potential inducers recognized by the regulatory system but also may properly adjust the levels of gene expression to the substrate availability.
Description8 páginas, 6 figuras, 2 tablas.
Publisher version (URL)http://dx.doi.org/10.1128/JB.00057-07
PMID: 17351041
Appears in Collections:(CABD) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.