English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/4069
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
Citado 67 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary
Autor : López-Onieva, Lourdes ; Fernández-Miñán, Ana ; González-Reyes, Acaimo
Palabras clave : Jak/Stat
Germline stem cells
Niche signalling
Drosophila oogenesis
Fecha de publicación : 2-ene-2008
Editor: Company of Biologists
Citación : Development 135(3): 533-540 (2008)
Resumen: The existence of specialised regulatory microenvironments or niches that sustain stable stem cell populations is well documented in many tissues. However, the specific mechanisms by which niche support (or stromal) cells govern stem cell maintenance remain largely unknown. Here we demonstrate that removal of the Jak/Stat pathway in support cells of the Drosophila ovarian niche leads to germline stem cell loss by differentiation. Conversely, ectopic Jak/Stat activation in support cells induces stem cell tumours, implying the presence of a signal relay between the stromal compartment and the stem cell population. We further show that ectopic Jak/Stat signalling in support cells augments dpp mRNA levels and increases the range of Dpp signalling, a Bmp2 orthologue known to act as a niche extrinsic factor required for female germline stem cell survival and division. Our results provide strong evidence for a model in which Jak/Stat signalling in somatic support cells regulates dpp transcription to define niche size and to maintain the adjacent germline stem cells in an undifferentiated state.
Descripción : 8 pages, 5 figures.-- PMID: 18171682 [PubMed].-- Printed version published Feb 2008.-- Supporting information (Suppl. table S1, figure S1) available at: http://dev.biologists.org/cgi/content/full/135/3/533/DC1
Versión del editor: http://dx.doi.org/10.1242/dev.016121
URI : http://hdl.handle.net/10261/4069
DOI: 10.1242/dev.016121
ISSN: 0950-1991
Aparece en las colecciones: (CABD) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
DEV 016121.pdfMain text file1,16 MBAdobe PDFVista previa
Suppl_table_S1.pdfTable S142,02 kBAdobe PDFVista previa
Suppl_figure_S1.jpgFigure S1135,2 kBJPEGVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.