Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/40655
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients

AutorCordero, Mario D. CSIC ORCID; Moreno-Fernández, Ana M.; Carmona-López, María Inés; Sánchez-Alcázar, José Antonio CSIC ORCID ; Fernández-Rodríguez, Ana; Navas, Plácido CSIC ORCID; Miguel, Manuel de
Palabras claveFibromyalgia
Blood mononuclear cells
Skin
Coenzyme Q10
Oxidative stress
Mitochondrial dysfunction
Ubiquinone
Leukocytes
Fecha de publicación1-jul-2010
EditorElsevier
CitaciónClinical Biochemistry 43(13-14): 1174-1176 (2010)
Resumen[Objectives]: Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration and mitochondrial dysfunction have been observed in patients with fibromyalgia (FM). The aim of this study was to analyze CoQ10 levels, mitochondrial dysfunction, and oxidative stress in plasma, blood mononuclear cells, and skin biopsies from FM patients. [Methods]: We studied CoQ10 level by HPLC in plasma, blood mononuclear cells, and skin obtained from patients with FM and healthy control subjects. Oxidative stress markers and mitochondrial respiratory chain enzyme activities were analysed in both plasma, blood mononuclear cells, and skin biopsies from FM patients. [Results]: Oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been observed in blood mononuclear cells and skin biopsies. [Conclusions]: In our patients, mitochondrial dysfunction and CoQ10 deficiency are present in several tissues. These results may contribute to the understanding of the pathophysiology of FM, and, moreover, CoQ10 deficiency could represent a good marker for the diagnosis of FM.
Descripción3 páginas, 1 figura, 1 tabla.
Versión del editorhttp://dx.doi.org/10.1016/j.clinbiochem.2010.06.013
URIhttp://hdl.handle.net/10261/40655
DOI10.1016/j.clinbiochem.2010.06.013
ISSN0009-9120
Aparece en las colecciones: (CABD) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

19
checked on 24-mar-2024

WEB OF SCIENCETM
Citations

17
checked on 28-feb-2024

Page view(s)

394
checked on 28-mar-2024

Download(s)

124
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.