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dc.contributor.authorMontero, Raquel-
dc.contributor.authorSánchez-Alcázar, José Antonio-
dc.contributor.authorBriones, Paz-
dc.contributor.authorRodríguez-Hernández, Ángeles-
dc.contributor.authorCordero, Mario D.-
dc.contributor.authorTrevisson, Eva-
dc.contributor.authorSalviati, Leonardo-
dc.contributor.authorPineda, Mercé-
dc.contributor.authorGarcía-Cazorla, Angels-
dc.contributor.authorNavas, Plácido-
dc.contributor.authorArtuch, Rafael-
dc.date.accessioned2011-10-05T13:12:58Z-
dc.date.available2011-10-05T13:12:58Z-
dc.date.issued2008-03-20-
dc.identifier.citationClinical Biochemistry - New York 41(9): 697-700 (2008)es_ES
dc.identifier.issn0009-9120-
dc.identifier.otherPMID: 18387363-
dc.identifier.urihttp://hdl.handle.net/10261/40650-
dc.description4 páginas, 2 tablas.es_ES
dc.description.abstractOBJECTIVES: To study CoQ(10) concentrations in muscle and fibroblast from 6 patients with a CoQ(10) deficiency syndrome. DESIGN AND METHODS: CoQ(10) was quantified by HPLC with electrochemical detection. RESULTS: Four out of the 6 cases showed muscle CoQ(10) deficiency plus a reduction of mitochondrial respiratory chain enzyme activities. All cases showed decreased CoQ(10) values in fibroblasts when compared with controls. CONCLUSIONS: Biochemical study of CoQ(10) in both muscle and fibroblasts seems advisable to demonstrate the deficiency in all patients.es_ES
dc.description.sponsorshipThis work was supported by grants PI040567, 041617 and 041351 from the FIS, Ministerio de Sanidad, Spain, and European Union contract LSHB-CT-2004-005151 (UBIGENES).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.publisherCanadian Society of Clinical Chemistses_ES
dc.rightsclosedAccesses_ES
dc.subjectBiological markerses_ES
dc.subjectElectron Transportes_ES
dc.subjectFibroblastses_ES
dc.subjectMitochondriaes_ES
dc.subjectUbiquinonees_ES
dc.subjectCoenzyme Q10es_ES
dc.titleAnalysis of Coenzyme Q10 in muscle and fibroblasts for the diagnosis of CoQ10 deficiency syndromeses_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1016/j.clinbiochem.2008.03.007-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.clinbiochem.2008.03.007es_ES
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