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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/40602
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dc.contributor.authorMoreno-Navarrete, José Maria-
dc.contributor.authorOrtega, Francisco J.-
dc.contributor.authorPérez-Pérez, Rafael-
dc.contributor.authorRicart, Wifredo-
dc.contributor.authorPeral, Belén-
dc.contributor.authorFernández-Real, José M.-
dc.date.accessioned2011-10-05T09:34:09Z-
dc.date.available2011-10-05T09:34:09Z-
dc.date.issued2011-08-17-
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism 96(11): E1816-E1825 (2011)es_ES
dc.identifier.issn0021-972X-
dc.identifier.urihttp://hdl.handle.net/10261/40602-
dc.description10 páginas, 6 figuras, 2 tablas.-- et al.-
dc.description.abstract[Context]: Six-transmembrane protein of prostate 2 (STAMP2) is a counter-regulator of inflammation and insulin resistance according to findings in mice. However, there have been contradictory reports in humans. [Objective]: We aimed to explore STAMP2 in association with inflammatory and metabolic status of human obesity. [Design, Patients, and Methods]: STAMP2 gene expression was analyzed in adipose tissue samples (171 visceral and 67 sc depots) and during human preadipocyte differentiation. Human adipocytes were treated with macrophage-conditioned medium, TNF-α, and rosiglitazone. [Results]: In visceral adipose tissue, STAMP2 gene expression was significantly decreased in obese subjects, mainly in obese subjects with type 2 diabetes. STAMP2 gene expression and protein were significantly and inversely associated with obesity phenotype measures (body mass index, waist, hip, and fat mass) and obesity-associated metabolic disturbances (systolic blood pressure and fasting glucose). In addition, STAMP2 gene expression was positively associated with lipogenic (FASN, ACC1, SREBP1, THRSP14, TRα, and TRα1), CAV1, IRS1, GLUT4, and CD206 gene expression. In sc adipose tissue, STAMP2 gene expression was not associated with metabolic parameters. In both fat depots, STAMP2 gene expression in stromovascular cells was significantly higher than in mature adipocytes. STAMP2 gene expression was significantly increased during the differentiation process in parallel to adipogenic genes, being increased in preadipocytes derived from lean subjects. Macrophage-conditioned medium (25%) and TNF-α (100 ng/ml) administration increased whereas rosiglitazone (2 μM) decreased significantly STAMP2 gene expression in human differentiated adipocytes. [Conclusions]: Decreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes.es_ES
dc.language.isoenges_ES
dc.publisherEndocrine Societyes_ES
dc.rightsopenAccesses_ES
dc.subjectSTAMP2es_ES
dc.subjectHuman obesityes_ES
dc.subjectGene expressiones_ES
dc.subjectType 2 diabeteses_ES
dc.titleDecreased STAMP2 expression in association with visceral adipose tissue dysfunctiones_ES
dc.typeartículoes_ES
dc.identifier.doi10.1210/jc.2011-0310-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1210/jc.2011-0310es_ES
dc.identifier.e-issn1945-7197-
dc.embargo.terms2012-08-17es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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