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Título

Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis

AutorJiménez, Gerardo ; González-Reyes, Acaimo ; Casanova, Jordi
Palabras claveDrosophila
Oncogenesis
Intercellular signaling events
Nasrat protein
Polehole protein
Fecha de publicación15-abr-2002
EditorCold Spring Harbor Laboratory. Press
CitaciónGenes and Development 16(8): 913–918 (2002)
ResumenStructural cell-surface and extracellular-matrix proteins modulate intercellular signaling events during development, but how this is achieved remains largely unknown. Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of the eggshell, and act in the Torso RTK signaling pathway that specifies the terminal regions of the embryo. Nasrat and Polehole are essential for extracellular accumulation of Torso-like, a factor secreted during oogenesis that initiates Torso receptor activation. Stabilization of secreted factors by specialized pericellular proteins may be a general mechanism during signaling and developmental patterning.
Descripción6 páginas, 4 figuras.
Versión del editorhttp://dx.doi.org/10.1101/gad.223902
URIhttp://hdl.handle.net/10261/4049
DOI10.1101/gad.223902
ISSN0890-9369
ReferenciasPMCID: PMC152353
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