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Title

An evaluation of the sexual differences in the accumulation of organochlorine compounds in children at birth and at the age of four years

AuthorsGrimalt, Joan O. ; Carrizo, Daniel; Garcí, Mercè; Font-Ribera, Laia; Ribas-Fitó, Núria; Torrent, Matties; Sunyer, Jordi
KeywordsOrganochlorine compounds
persistent organic pollutants
breastfeeding
polychlorobiphenyls
4,4’-DDE
pollutants in cord serum
background concentrations of organochlorine compounds in children sera
newborns
Issue Date1-Feb-2010
PublisherElsevier
CitationEnvironmental Research 110 (3): 244-250 (2010)
AbstractThis study of the body burden and serum concentrations, of organochlorine compounds (OCs), represents a general population in a cohort from Menorca Island (birth 1997-1998) of children at birth and at four years of age; the study has shown that the concentrations of hexachlorobenzene (HCB), 4,4’-DDE, 4,4’-DDT, polychlorobiphenyl (PCB) congeners #153, #138 and #180 and total PCBs in sera collected at four years exhibit much higher values in breastfed children than in those fed with formula, e.g. HCB 0.48 vs 0.21 ng/ml, β-HCH 0.32 vs 0.24 ng/ml, total DDTs 2.2 vs 0.57 ng/ml, total PCBs 1.4 vs 0.52 ng/ml, respectively. Comparison of gender differences in four years old children shows higher concentrations of all examined OCs in females than in males with the exception of HCB and PeCB in breastfed children which are higher in males than in females, e.g. β-HCH 0.34 vs 0.28 ng/ml, total DDTs 2.6 vs 1.7 ng/ml, total PCBs 1.6 vs 1.0 ng/ml, respectively, for breastfed children and e.g. β-HCH 0.23 vs 0.19 ng/ml, total DDTs 0.59 vs 0.48 ng/ml, total PCBs 0.58 vs 0.45 ng/ml, respectively, for formula fed children. Gender comparison of the body burden between children fed with breast milk or formula also shows higher concentrations in females than males, e.g. β-HCH 0.47 vs 0.35 µg, total DDTs 3.0 vs 1.8 µg, total PCBs 1.9 vs 1.2 µg, respectively, for breastfed children, and β-HCH 0.39 vs 0.17 µg, total DDTs 0.48 vs 0.27 µg, total PCBs 0.66 vs 0.55 µg, respectively, for formula fed children. The results may suggest a higher capacity in female children for the retention of OC incorporated through breast feeding. However, these results should be taken with caution because the differences of the gender averages have low statistically significance when evaluated with the Student test.
Description7 páginas, 2 figuras, 5 tablas.
Publisher version (URL)http://dx.doi.org/10.1016/j.envres.2010.01.005
URIhttp://hdl.handle.net/10261/40135
DOI10.1016/j.envres.2010.01.005
Appears in Collections:(IDAEA) Artículos
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Table 5 new.docTabla 562,5 kBMicrosoft WordView/Open
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