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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/40002
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dc.contributor.authorGómez, Irene-
dc.contributor.authorLarriba, María Jesús-
dc.contributor.authorGarcía de Herreros, Antonio-
dc.contributor.authorBonilla, Félix-
dc.contributor.authorGarcía, José M.-
dc.date.accessioned2011-09-26T10:23:38Z-
dc.date.available2011-09-26T10:23:38Z-
dc.date.issued2011-03-28-
dc.identifier.citationPLoS ONE 6(3): e18023 (2011)es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10261/40002-
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.-
dc.description.abstractTWIST1 is a transcription factor that belongs to the family of basic helix-loop-helix proteins involved in epithelial-to-mesenchymal transition and invasion processes. The TWIST1 protein possesses oncogenic, drug-resistant, angiogenic and invasive properties, and has been related with several human tumors and other pathologies. Colorectal cancer is one of the tumors in which TWIST1 is over-expressed, but its involvement in the clinical outcome of the disease is still unclear. We tested, by RT-PCR, the expression levels of TWIST1 in normal and tumor paired-sample tissues from a series of 151 colorectal cancer patients, in order to investigate its prognostic value as a tumor marker. TWIST1 expression was restricted to tumor tissues (86.1%) and correlated with lymph node metastasis (LNM). Adjusted analysis showed that the expression levels of TWIST1 correlated with overall survival (OS) and disease-free survival (DFS). Importantly, TWIST1 expression levels predicted OS specifically at stages I and II. Moreover, patients with stage II tumors and high TWIST1 levels showed even shorter survival than patients with stage III tumors. These results suggest that TWIST1 expression levels could be a tumor indicator in stage II patients and help select patients at greater risk of poor prognosis who might benefit from adjuvant chemotherapy.es_ES
dc.description.sponsorshipThis study was supported by grants from: Foundation AECC, S-GEN/0266/2006, RD06/0020/0020,SAF2010-20750 and RD06/0020/0040. JMG is supported by ISCIII-CP08/00217.-
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's version-
dc.rightsopenAccesses_ES
dc.subjectEpithelial-mesenchymal transitiones_ES
dc.subjectTranscription factor snailes_ES
dc.subjectE-cadherin expressiones_ES
dc.subjectBreast cancer cellses_ES
dc.subjectColon canceres_ES
dc.titleTWIST1 is expressed in colorectal carcinomas and predicts patient survivales_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0018023-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0018023es_ES
dc.identifier.pmid21464926-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeartículo-
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