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Título: | Histone H1 Poly[ADP]-Ribosylation Regulates the Chromatin Alterations Required for Learning Consolidation |
Autor: | Fontán-Lozano, Ángela CSIC ORCID; Suárez-Pereira, Irene; Horrillo, Angélica CSIC ; Pozo-Martín, Yaiza del; Hmadcha, Abdelkrim CSIC ORCID; Carrión Rodríguez, Ángel Manuel CSIC ORCID | Fecha de publicación: | oct-2010 | Editor: | Society for Neuroscience | Citación: | Journal of Neuroscience 30(40): 13305-13313 (2010) | Resumen: | Memory formation requires changes in gene expression, which are regulated by the activation of transcription factors and by changes in epigenetic factors. Poly[ADP]-ribosylation of nuclear proteins has been postulated as a chromatin modification involved in memory consolidation, although the mechanisms involved are not well characterized. Here we demonstrate that poly[ADP]-ribose polymerase 1 (PARP-1) activity and the poly[ADP]-ribosylation of proteins over a specific time course is required for the changes in synaptic plasticity related to memory stabilization in mice. At the molecular level, histone H1 poly[ADP]-ribosylation was evident in the hippocampus after the acquisition period, and it was selectively released in a PARP-1-dependent manner at the promoters of cAMP response element-binding protein and nuclear factor-κB dependent genes associated with learning and memory. These findings suggest that histone H1 poly[ADP]-ribosylation, and its loss at specific loci, is an epigenetic mechanism involved in the reprogramming of neuronal gene expression required for memory consolidation. | Descripción: | 9 páginas, 6 figuras. | Versión del editor: | http://dx.doi.org/10.1523/JNEUROSCI.3010-10.2010 | URI: | http://hdl.handle.net/10261/38970 | DOI: | 10.1523/JNEUROSCI.3010-10.2010 | E-ISSN: | 1529-2401 |
Aparece en las colecciones: | (CABIMER) Artículos |
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