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dc.contributor.authorSubtil-Rodríguez, Alicia-
dc.contributor.authorReyes, José C.-
dc.date.accessioned2011-08-09T11:57:04Z-
dc.date.available2011-08-09T11:57:04Z-
dc.date.issued2010-
dc.identifier.citationEmbo Reports 11(10): 751-757 (2010)es_ES
dc.identifier.issn1469-221X-
dc.identifier.urihttp://hdl.handle.net/10261/38532-
dc.description7 páginas, 5 figuras.es_ES
dc.description.abstractRNA polymerase II (RNAPII) transcribes genes in a chromatin context. We have designed a system to investigate the role of chromatin remodelling during elongation in vivo, which involves inserting a strong nucleosome-positioning sequence between a promoter and a reporter gene. Our data indicate that a nucleosome positioned in the body of a transcription unit impairs RNAPII progression, provokes RNAPII accumulation upstream to the positioned nucleosome and reduces transcription. By using this system, we show that BRG1, the enzymatic motor of the SWI–SNF chromatin-remodelling complex, is recruited to the positioned nucleosome in a transcription elongation-dependent manner and facilitates traversal of the nucleosome by RNAPII.es_ES
dc.description.sponsorshipThis study was supported by Ministerio de Educación y Ciencia (BFU2008-00238, CSD2006-00049) and by Junta de Andalucía (P06-CVI-01400).es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsclosedAccesses_ES
dc.titleBRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivoes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/embor.2010.131-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/embor.2010.131es_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderJunta de Andalucía-
dc.relation.csic-
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