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dc.contributor.authorPinacho Crisóstomo, Fernando R.-
dc.contributor.authorPadrón, José M.-
dc.contributor.authorMartín, Tomás-
dc.contributor.authorVillar, Jesús-
dc.contributor.authorMartín, Víctor S.-
dc.date.accessioned2011-08-05T10:07:18Z-
dc.date.available2011-08-05T10:07:18Z-
dc.date.issued2006-04-
dc.identifier.citationEuropean Journal of Organic Chemistry 8: 1910-1916 (2006)es_ES
dc.identifier.issn1434-193X-
dc.identifier.urihttp://hdl.handle.net/10261/38424-
dc.description7 páginas, 3 figuras, 1 tabla, 4 esquemas.es_ES
dc.description.abstractshort and efficient enantiomeric synthesis of fused tetrahydrofuran derivatives is reported. The methodology is based on a regio- and stereoselective double exo-cyclization of enantiomeric bis-epoxy-diols. The six stereocenters of the bis-epoxy diols were introduced by the application of Katsuki–Sharpless asymmetric epoxidation and Sharpless asymmetric dihydroxylation reactions. In vitro cytotoxicities on HL60 human promyelocytic leukemia cells were determined for the bicyclic products. Active products showed exceptionally steep dose–response curves and DNA laddering.es_ES
dc.description.sponsorshipThis research was supported by the Ministerio de Ciencia y Tecnología of Spain (PPQ2002-04361-C04-02) and the Canary Islands Government. J.M.P. is a recipient of a postdoctoral fellowship from the ICIC. F.R.P.C. thanks CajaCanarias for a FPI fellowship. T.M. thanks the Spanish MCYT-FSE for a Ramón y Cajal contract.es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsclosedAccesses_ES
dc.subjectAntitumor agentses_ES
dc.subjectCyclic etherses_ES
dc.subjectAsymmetric synthesises_ES
dc.subjectStructure–activity relationshipses_ES
dc.titleA Short and Efficient Enantiomeric Synthesis of Antitumor Fused Tetrahydrofuranses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1002/ejoc.200500842-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1002/ejoc.200500842es_ES
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)-
dc.contributor.funderGobierno de Canarias-
dc.contributor.funderInstituto Canario de Investigación del Cáncer-
dc.contributor.funderCaja Canarias-
dc.contributor.funderEuropean Commission-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006280es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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