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Citrate inhibition of phosphofructokinase and the Pasteur effect

AuthorsSalas, María Luisa; Viñuela, Eladio; Salas, Margarita ; Sols, Alberto
Issue Date1965
CitationBiochemical and Biophysical Research Communications 19(3): 371-376 (1965)
AbstractA large amount of recent evidence clearly indicates that the regulation of phosphofructokinase (PFK) activity is fundamental in the control of glycolysis (Lowry and Passonneau, 1964) through a series of feedback mechanisms (Sols et., 1963). Endproduct inhibition of PFK by ATP (ViRuela et. , 1963) may account for the Pasteur effect in certain tissues (Wu, 1964) . Nevertheless, it has been reported that in glucose utilizing yeast, where both the Pasteur effect and an involvement of PFK in it were first observ - ed, the level of ATP is essentially the same in aerobiosis and an- aerobiosis (1-ynen et. , 1959) . Evidence reported here indicates that an additional feedback inhibition involving citrate may account for the aerobic regulation of PFK activity in yeast.
Publisher version (URL)http://dx.doi.org/10.1016/0006-291X(65)90471-7
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