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Title

Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain

AuthorsQuintero, Francisco J. ; Martínez-Atienza, Juliana ; Villalta, Irene ; Mendoza, Imelda ; Pardo, José M.
KeywordsIon transport
Salinity
Spdium tolerance
Issue DateJan-2011
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences of the USA 108 (6): 2611-2616 (2011)
AbstractThe plasma membrane sodium/proton exchanger Salt-Overly-Sensitive 1 (SOS1) is a critical salt tolerance determinant in plants. The SOS2-SOS3 calcium-dependent protein kinase complex up-regulates SOS1 activity, but the mechanistic details of this crucial event remain unresolved. Here we show that SOS1 is maintained in a resting state by a C-terminal auto-inhibitory domain that is the target of SOS2-SOS3. The auto-inhibitory domain interacts intramolecularly with an adjacent domain of SOS1 that is essential for activity. SOS1 is relieved from auto-inhibition upon phosphorylation of the auto-inhibitory domain by SOS2-SOS3. Mutation of the SOS2 phosphorylation and recognition site impeded the activation of SOS1 in vivo and in vitro. Additional amino acid residues critically important for SOS1 activity and regulation were identified in a genetic screen for hypermorphic alleles.
DescriptionQuintero et al.-- 6 páginas, 4 figuras, 25 referencias y 4 páginas adicionales con 5 figuras y 2 tablas.
Publisher version (URL)http://dx.doi.org/10.1073/pnas.1018921108
URIhttp://hdl.handle.net/10261/37957
DOI10.1073/pnas.1018921108
ISSN0027-8424
Appears in Collections:(IRNAS) Artículos
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