English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37870
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Enantioselective synthesis of cis-α-substituted cycloalkanols and trans-cycloalkyl amines thereof

AuthorsFernández, Rosario; Ros, Abel ; Magriz, Antonio ; Dietrich, Hansjörg; Lassaletta, José M.
KeywordsAsymmetric catalysis
Amines
Transfer hydrogenation
Dynamic kinetic resolution
Issue Date7-May-2007
PublisherElsevier
CitationTetrahedron 63(29): 6755-6763 (2007)
AbstractThe diastereo- and enantioselective syntheses of trans-cycloalkyl amines was accomplished through a three-step sequence consisting of: (1) asymmetric transfer hydrogenation through dynamic kinetic resolution of bicyclic and monocyclic α-substituted ketones using HCO2H/Et3N as the hydrogen source and TsDPEN-based Ru(II) catalysts, (2) nucleophilic hydroxyl to azide substitution of the resulting cis-cycloalkanols using diphenyl phosphoryl azide under modified Mitsunobu conditions, and (3) reduction of the trans-azide intermediates with LiAlH4 of PPh3/H2O to the desired targets.
Description9 páginas, 1 figura, 2 tablas, 6 esquemas.
Publisher version (URL)http://dx.doi.org/10.1016/j.tet.2007.04.075
URIhttp://hdl.handle.net/10261/37870
DOI10.1016/j.tet.2007.04.075
ISSN0040-4020
Appears in Collections:(IIQ) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.