Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/37839COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Martín-Villar, Ester | - |
| dc.contributor.author | Fernández-Muñoz, Beatriz | - |
| dc.contributor.author | Yurrita, María M. | - |
| dc.contributor.author | Megías, Diego | - |
| dc.contributor.author | Pérez-Gómez, Eduardo | - |
| dc.contributor.author | Quintanilla, Miguel | - |
| dc.date.accessioned | 2011-07-19T10:09:30Z | - |
| dc.date.available | 2011-07-19T10:09:30Z | - |
| dc.date.issued | 2010-12-15 | - |
| dc.identifier.citation | Molecular Biology of the Cell 21(24): 4387-4399 (2010) | es_ES |
| dc.identifier.uri | http://hdl.handle.net/10261/37839 | - |
| dc.description | This article is under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.-- et al. | - |
| dc.description.abstract | Podoplanin is a transmembrane glycoprotein up-regulated in different human tumors, especially those derived from squamous stratified epithelia (SCCs). Its expression in tumor cells is linked to increased cell migration and invasiveness; however, the mechanisms underlying this process remain poorly understood. Here we report that CD44, the major hyaluronan (HA) receptor, is a novel partner for podoplanin. Expression of the CD44 standard isoform (CD44s) is coordinately up-regulated together with that of podoplanin during progression to highly aggressive SCCs in a mouse skin model of carcinogenesis, and during epithelial-mesenchymal transition (EMT). In carcinoma cells, CD44 and podoplanin colocalize at cell surface protrusions. Moreover, CD44 recruitment promoted by HA-coated beads or cross-linking with a specific CD44 antibody induced corecruitment of podoplanin. Podoplanin-CD44s interaction was demonstrated both by coimmunoprecipitation experiments and, in vivo, by fluorescence resonance energy transfer/fluorescence lifetime imaging microscopy (FRET/FLIM), the later confirming its association on the plasma membrane of cells with a migratory phenotype. Importantly, we also show that podoplanin promotes directional persistence of motility in epithelial cells, a feature that requires CD44, and that both molecules cooperate to promote directional migration in SCC cells. Our results support a role for CD44-podoplanin interaction in driving tumor cell migration during malignancy. | es_ES |
| dc.description.sponsorship | This work was supported by grant SAF2007-63821 from the Spanish Ministry of Science and Innovation (to M.Q.), the Royal Society University Research Fellowship (to M.P.), Medical Research Council (to G.E.J.) EU FP7 T3Net Consortium (GEJ), and Cancer Research UK (to G.E.J. and E.M.V.). | - |
| dc.language.iso | eng | es_ES |
| dc.publisher | American Society for Cell Biology | es_ES |
| dc.rights | openAccess | es_ES |
| dc.title | Podoplanin associates with CD44 to promote directional cell migration | es_ES |
| dc.type | artículo | es_ES |
| dc.identifier.doi | 10.1091/mbc.E10-06-0489 | - |
| dc.description.peerreviewed | Peer reviewed | es_ES |
| dc.relation.publisherversion | http://dx.doi.org/10.1091/mbc.E10-06-0489 | es_ES |
| dc.identifier.e-issn | 1939-4586 | - |
| dc.rights.license | http://creativecommons.org/licenses/by-nc-sa/3.0 | - |
| dc.identifier.pmid | 20962267 | - |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.openairetype | artículo | - |
| item.grantfulltext | open | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | With Fulltext | - |
| item.languageiso639-1 | en | - |
| Aparece en las colecciones: | (IIBM) Artículos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Podoplanin.pdf | 3,38 MB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
56
checked on 17-abr-2024
SCOPUSTM
Citations
109
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
103
checked on 26-feb-2024
Page view(s)
398
checked on 19-abr-2024
Download(s)
325
checked on 19-abr-2024
