Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/37745
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Cancer Abolishes the Tissue Type–Specific Differences in the Phenotype of Energetic Metabolism |
Autor: | Acebo País, Paloma CSIC; Giner-Sánchez, Daniel; Calvo, Piedad; Blanco-Rivero, Amaya; Ortega, Álvaro D.; Fernández, Pedro L.; Roncador, Giovanna; Fernández-Malavé, Edgar CSIC; Chamorro, Margarita CSIC; Cuezva, José M. CSIC ORCID | Palabras clave: | Tumors Glycolytic pathway β-F1-ATPase hallmark |
Fecha de publicación: | 2009 | Editor: | Elsevier | Citación: | Translational Oncology 2 (3): 138–145 (2009) | Resumen: | Nowadays, cellular bioenergetics has become a central issue of investigation in cancer biology. Recently, the metabolic activity of the cancer cell has been shown to correlate with a proteomic index that informs of the relative mitochondrial activity of the cell. Within this new field of investigation, we report herein the production and characterization of high-affinity monoclonal antibodies against proteins of the “bioenergetic signature” of the cell. The use of recombinant proteins and antibodies against the mitochondrial β-F1-ATPase and Hsp60 proteins and the enzymes of the glycolytic pathway glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase M2 in quantitative assays provide, for the first time, the actual amount of these proteins in normal and tumor surgical specimens of breast, lung, and esophagus. The application of this methodology affords a straightforward proteomic signature that quantifies the variable energetic demand of human tissues. Furthermore, the results show an unanticipated finding: tumors from different tissues and/or histological types have the same proteomic signature of energetic metabolism. Therefore, the results indicate that cancer abolishes the tissue-specific differences in the bioenergetic phenotype of mitochondria. Overall, the results support that energetic metabolism represents an additional hallmark of the phenotype of the cancer cell and a promising target for the treatment of diverse neoplasias. | Versión del editor: | http://dx.doi.org/10.1593/tlo.09106 | URI: | http://hdl.handle.net/10261/37745 | DOI: | 10.1593/tlo.09106 | ISSN: | 1936-5233 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
JMCuezva_TransOncol_2009.pdf | 546,53 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
24
checked on 13-mar-2024
SCOPUSTM
Citations
50
checked on 15-mar-2024
WEB OF SCIENCETM
Citations
43
checked on 25-feb-2024
Page view(s)
366
checked on 18-mar-2024
Download(s)
245
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.