English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37744
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

The tumor suppressor function of mitochondria: Translation into the clinics

AuthorsCuezva, José M. ; Ortega, Álvaro D.; Willers, Imke M. ; Sánchez-Cenizo, Laura ; Aldea, Marcos; Sánchez-Aragó, María
KeywordsMitochondria
Mitochondrial β-F1-ATPase
Cancer
Issue DateDec-2009
PublisherElsevier
CitationBiochimica et Biophysica Acta - Molecular Basis of Disease 1792(12):1145-58 (2009)
AbstractRecently, the inevitable metabolic reprogramming experienced by cancer cells as a result of the onset of cellular proliferation has been added to the list of hallmarks of the cancer cell phenotype. Proliferation is bound to the synchronous fluctuation of cycles of an increased glycolysis concurrent with a restrained oxidative phosphorylation. Mitochondria are key players in the metabolic cycling experienced during proliferation because of their essential roles in the transduction of biological energy and in defining the life-death fate of the cell. These two activities are molecularly and functionally integrated and are both targets of commonly altered cancer genes. Moreover, energetic metabolism of the cancer cell also affords a target to develop new therapies because the activity of mitochondria has an unquestionable tumor suppressor function. In this review, we summarize most of these findings paying special attention to the opportunity that translation of energetic metabolism into the clinics could afford for the management of cancer patients. More specifically, we emphasize the role that mitochondrial beta-F1-ATPase has as a marker for the prognosis of different cancer patients as well as in predicting the tumor response to therapy.
Publisher version (URL)http://dx.doi.org/10.1016/j.bbadis.2009.01.006
URIhttp://hdl.handle.net/10261/37744
DOI10.1016/j.bbadis.2009.01.006
ISSN0006-3002
Appears in Collections:(CBM) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.