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dc.contributor.authorLópez-Prados, Javier-
dc.contributor.authorCuevas, Félix-
dc.contributor.authorReichardt, Niels Christian-
dc.contributor.authorde Paz, José L.-
dc.contributor.authorMorales, Ezequiel Q.-
dc.contributor.authorMartín-Lomas, Manuel-
dc.date.accessioned2011-07-11T08:53:07Z-
dc.date.available2011-07-11T08:53:07Z-
dc.date.issued2004-12-23-
dc.identifier.citationOrganic and Biomolecular Chemistry 3(5): 764-786 (2005)es_ES
dc.identifier.issn1177-0520-
dc.identifier.urihttp://hdl.handle.net/10261/37634-
dc.description23 páginas, 5 figuras, 11 esquemas.es_ES
dc.description.abstractThe binding modes of a series of molecules, containing the glucosamine (1→6) myo-inositol structural motif, into the ATP binding site of the catalytic subunit of cAMP-dependent protein kinase (PKA) have been analysed using molecular docking. These calculations predict that the presence of a phosphate group at the non-reducing end in pseudodisaccharide and pseudotrisaccharide structures properly orientate the molecule into the binding site and that pseudotrisaccharide structures present the best shape complementarity. Therefore, pseudodisaccharides and pseudotrisaccharides have been synthesised from common intermediates using effective synthetic strategies. On the basis of this synthetic chemistry, the feasibility of constructing small pseudotrisaccharide libraries on solid-phase using the same intermediates has been explored. The results from the biological evaluation of these molecules provide additional support to an insulin-mediated signalling system which involves the intermediacy of inositolphosphoglycans as putative insulin mediators.es_ES
dc.description.sponsorshipWe thank the Spanish Ministry of Science and Technology (Grant BQU 2002-03734) and Rodaris Pharmaceuticals for financial support. N.-C. Reichardt thanks the European Union for a fellowship (Grant HRN-CT-2000-00001/Glycotrain).es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistry (Great Britain)es_ES
dc.rightsclosedAccesses_ES
dc.subjectBinding modeses_ES
dc.subjectMolecular structurees_ES
dc.subjectInositolses_ES
dc.subjectPhosphateses_ES
dc.subjectGlucosaminees_ES
dc.subjectCatalytices_ES
dc.subjectInsulines_ES
dc.titleDesign and synthesis of inositolphosphoglycan putative insulin mediatorses_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1039/B418041K-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1039/B418041Kes_ES
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