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Design and synthesis of inositolphosphoglycan putative insulin mediators

AuthorsLópez-Prados, Javier; Cuevas, Félix; Reichardt, Niels Christian; de Paz, José L.; Morales, Ezequiel Q.; Martín-Lomas, Manuel
KeywordsBinding modes
Molecular structure
Issue Date23-Dec-2004
PublisherRoyal Society of Chemistry (Great Britain)
CitationOrganic and Biomolecular Chemistry 3(5): 764-786 (2005)
AbstractThe binding modes of a series of molecules, containing the glucosamine (1→6) myo-inositol structural motif, into the ATP binding site of the catalytic subunit of cAMP-dependent protein kinase (PKA) have been analysed using molecular docking. These calculations predict that the presence of a phosphate group at the non-reducing end in pseudodisaccharide and pseudotrisaccharide structures properly orientate the molecule into the binding site and that pseudotrisaccharide structures present the best shape complementarity. Therefore, pseudodisaccharides and pseudotrisaccharides have been synthesised from common intermediates using effective synthetic strategies. On the basis of this synthetic chemistry, the feasibility of constructing small pseudotrisaccharide libraries on solid-phase using the same intermediates has been explored. The results from the biological evaluation of these molecules provide additional support to an insulin-mediated signalling system which involves the intermediacy of inositolphosphoglycans as putative insulin mediators.
Description23 páginas, 5 figuras, 11 esquemas.
Publisher version (URL)http://dx.doi.org/10.1039/B418041K
Appears in Collections:(IIQ) Artículos
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