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Title

Preorganized macromolecular gene delivery systems: amphiphilic β-cyclodextrin “click clusters”

AuthorsMéndez-Ardoy, Alejandro ; Gómez García, Marta ; Ortiz-Mellet, Carmen; Sevillano Trapero, Natalia; Girón González, María Dolores; Salto González, Rafael; Santoyo-González, F.; García-Fernández, José Manuel
KeywordsAlkynes
Azides
Copper
DNA
Macromolecular substances
Nanoparticles
Beta-Cyclodextrins
Catalysis
Issue Date5-May-2009
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 7(13): 2681-2684 (2009)
AbstractGene delivery systems based on the beta-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling ("click chemistry") and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.
Description4 páginas, 2 figuras, 2 esquemas.
Publisher version (URL)http://dx.doi.org/10.1039/B903635K
URIhttp://hdl.handle.net/10261/37631
DOI10.1039/B903635K
ISSN1177-0520
Appears in Collections:(IIQ) Artículos
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