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dc.contributor.authorCelis, José F. de-
dc.contributor.authorBarrio, Rosa-
dc.date.accessioned2011-07-07T17:09:51Z-
dc.date.available2011-07-07T17:09:51Z-
dc.date.issued2008-10-28-
dc.identifier.citationInternational Journal of Developmental Biology 53: 1385 - 1398 (2008)es_ES
dc.identifier.issn0214-6282-
dc.identifier.urihttp://hdl.handle.net/10261/37592-
dc.description.abstractThe genes of the spalt (sal) family play fundamental roles during animal development. The two members of this family in Drosophila, spalt (sal) and spalt-related (salr) encode Zn-finger transcription factors that link the Decapentaplegic (Dpp)/BMP signalling pathway to the patterning of the wing. They are regulated by the Dpp pathway in the wing disc, and they were shown to mediate some of the morphogenetic activities of the Dpp/BMP4 secreted ligand. The sal genes were initially found by virtue of mutations that produce homeotic transformations in the head and tail of the Drosophila embryo. Since then, a number of other requirements have been associated to these genes in Drosophila, including morphogenesis of the respiratory system, cell fate specification of sensory organs and the differentiation of several photoreceptor cells, among others. Vertebrate sal orthologues (spalt-like/sall) have also important developmental roles during neural development and organogenesis, and at least two human sall genes are linked to the genetic diseases Townes Brocks Syndrome (TBS; SALL1 ) and Okihiro Syndrome (OS; SALL4 ). In this review, we will summarize the main characteristics of the sall genes and proteins, pointing out to the similarities in their developmental roles during Drosophila and vertebrate development.es_ES
dc.description.sponsorshipSánchez. J.F.dC. is supported by an institutional grant from the Ramón Areces Foundation to the Centro de Biología Molecular “Severo Ochoa” and by the Ministerio de Educación y Ciencia (BFU2006-06501). R.B. belongs to the Cajal Program (MEC) and is recipient of grants from the Spanish Ministry of Education (BFU2005-00257), the Department of Industry, Tourism and Trade of the Government of the Autonomous Community of the Basque Country (Etortek Research Programs 2005/2006) and from the Innovation Technology Department of the Bizkaia County.es_ES
dc.language.isoenges_ES
dc.publisherUniversidad del País Vascoes_ES
dc.rightsopenAccesses_ES
dc.subjectSpaltes_ES
dc.subjectGene regulationes_ES
dc.subjectOrganogenesises_ES
dc.subjectEmbryonic developmentes_ES
dc.titleRegulation and function of Spalt proteins during animal developmentes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1387/ijdb.072408jd-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1387/ijdb.072408jdes_ES
dc.contributor.funderFundación Ramón Areces-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderEusko Jaurlaritza-
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003086es_ES
dc.identifier.pmid19247946-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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