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Title

Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: A case–control study

AuthorsKlassert, Tilman E.; Sánchez, Juan J.; Almeida, Teresa A.; Candenas, M. Luz ; Pinto Pérez, Francisco M. ; Acosta, Orlando; Hernández, Mariano
KeywordsTachykinins
Asthma
Polymorphism
Association study
Issue DateOct-2010
PublisherElsevier
CitationJournal of Neuroimmunology 227(1-2): 202-207 (2010)
AbstractSince tachykinins appear to be involved in the pathogenesis of allergic asthma, we investigated a possible association between 28 single nucleotide polymorphisms of the tachykinin genes TAC1, TAC3 and TAC4, and asthma susceptibility. A case–control study was conducted on 102 patients and 100 healthy subjects from the Canary Islands (Spain). A significant association with asthma was observed for two SNPs: rs2291855 in the TAC3 gene conferring asthma protection (Odds ratio [OR]: 0.46; 95% Confidence Interval [CI]: 0.22–0.97; P = 0.038), and rs4794068 in the TAC4 gene associated with an increased risk for asthma (OR: 1.94; 95% CI: 1.06–3.54; P = 0.03). The present study represents a preliminary step in elucidating the association between tachykinin gene polymorphisms and asthma susceptibility.
Description6 páginas, 1 figura, 4 tablas.
Publisher version (URL)http://dx.doi.org/10.1016/j.jneuroim.2010.05.044
URI10261/37527
DOI10.1016/j.jneuroim.2010.05.044
ISSN0165-5728
Appears in Collections:(IIQ) Artículos
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