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Título: | Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods |
Autor: | Canales, Ángeles CSIC ORCID; Fayos, Rosa CSIC; Angulo, Jesús CSIC ORCID ; Ojeda, Rafael; Martín-Pastor, Manuel; Nieto, Pedro M. CSIC ORCID ; Martín-Lomas, Manuel CSIC; Lozano, R.M. CSIC ORCID ; Giménez-Gallego, Guillermo CSIC; Jiménez-Barbero, Jesús CSIC ORCID | Palabras clave: | Chemical shift perturbation Fibroblast growth factors Heparan sulfate oligosaccharides Protein-carbohydrate interactions Relaxation analysis |
Fecha de publicación: | 2006 | Editor: | Springer Nature | Citación: | Journal of Biomolecular NMR 35(4): 225-239 (2006) | Resumen: | The binding site and backbone dynamics of a bioactive complex formed by the acidic fibroblast growth factor (FGF-1) and a specifically designed heparin hexasaccharide has been investigated by HSQC and relaxation NMR methods. The comparison of the relaxation data for the free and bound states has allowed showing that the complex is monomeric, and still induces mutagenesis, and that the protein backbone presents reduced motion in different timescale in its bound state, except in certain points that are involved in the interaction with the fibroblast growth factor receptor (FGFR). | Descripción: | 15 páginas, 7 figuras, 1 tabla. | Versión del editor: | http://dx.doi.org/10.1007/s10858-006-9024-y | URI: | http://hdl.handle.net/10261/37507 | DOI: | 10.1007/s10858-006-9024-y | ISSN: | 0925-2738 |
Aparece en las colecciones: | (IIQ) Artículos (CIB) Artículos |
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